CDC6

CDC6
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2CCH, 2CCI, 4I5L, 4I5N
Dynodwyr
Cyfenwau	CDC6, CDC18L, HsCDC18, Hscell division cycle 6, MGORS5
Dynodwyr allanol	OMIM: 602627 HomoloGene: 68172 GeneCards: CDC6
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nucleotide binding; • kinase binding; • GO:0001948, GO:0016582 protein binding; • ATP binding; • DNA replication origin binding;
Cydrannau o'r gell	• spindle pole; • spindle midzone; • cnewyllyn cell; • cytoplasm; • nucleolus; • nucleoplasm; • cytosol;
Prosesau biolegol	• regulation of cyclin-dependent protein serine/threonine kinase activity; • cellular response to vasopressin; • positive regulation of fibroblast proliferation; • negative regulation of DNA replication; • regulation of transcription involved in G1/S transition of mitotic cell cycle; • Cellraniad; • positive regulation of cytokinesis; • DNA replication checkpoint signaling; • DNA replication; • cellular response to angiotensin; • DNA replication initiation; • traversing start control point of mitotic cell cycle; • positive regulation of chromosome segregation; • positive regulation of cyclin-dependent protein serine/threonine kinase activity; • regulation of mitotic metaphase/anaphase transition; • cell cycle; • negative regulation of cell population proliferation; • GO:0007067 Mitosis; • G1/S transition of mitotic cell cycle; • mitotic DNA replication checkpoint signaling;
	Sources:Amigo / QuickGO
Orthologau
	990
	n/a
	ENSG00000094804
	n/a
	Q99741
	n/a
	NM_001254
	n/a
	NP_001245
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CDC6 yw CDC6 a elwir hefyd yn Cell division cycle 6 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q21.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CDC6.

CDC18L
HsCDC6
MGORS5
HsCDC18

Llyfryddiaeth

"The DNA replication protein Cdc6 inhibits the microtubule-organizing activity of the centrosome. ". J Biol Chem. 2017. PMID 28827311.
"High expression of CDC6 is associated with accelerated cell proliferation and poor prognosis of epithelial ovarian cancer. ". Pathol Res Pract. 2016. PMID 26920249.
"DNA replication initiator Cdc6 also regulates ribosomal DNA transcription initiation. ". J Cell Sci. 2016. PMID 26872786.
"Spatio-temporal regulation of the human licensing factor Cdc6 in replication and mitosis. ". Cell Cycle. 2015. PMID 25875233.
"Cdc6 localizes to S- and G2-phase centrosomes in a cell cycle-dependent manner.". Biochem Biophys Res Commun. 2015. PMID 25498505.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CDC6 - Cronfa NCBI

[1]

[2]