CDK2

CDK2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1AQ1, 1B38, 1B39, 1BUH, 1CKP, 1DI8, 1DM2, 1E1V, 1E1X, 1E9H, 1F5Q, 1FIN, 1FQ1, 1FVT, 1FVV, 1G5S, 1GIH, 1GII, 1GIJ, 1GY3, 1GZ8, 1H00, 1H01, 1H07, 1H08, 1H0V, 1H0W, 1H1P, 1H1Q, 1H1R, 1H1S, 1H24, 1H25, 1H26, 1H27, 1H28, 1HCK, 1HCL, 1JST, 1JSU, 1JSV, 1JVP, 1KE5, 1KE6, 1KE7, 1KE8, 1KE9, 1OGU, 1OI9, 1OIQ, 1OIR, 1OIT, 1OIU, 1OIY, 1OKV, 1OKW, 1OL1, 1OL2, 1P2A, 1P5E, 1PF8, 1PKD, 1PW2, 1PXI, 1PXJ, 1PXK, 1PXL, 1PXM, 1PXN, 1PXO, 1PXP, 1PYE, 1QMZ, 1R78, 1URC, 1URW, 1V1K, 1VYW, 1VYZ, 1W0X, 1W8C, 1W98, 1WCC, 1Y8Y, 1Y91, 1YKR, 2A0C, 2A4L, 2B52, 2B53, 2B54, 2B55, 2BHE, 2BHH, 2BKZ, 2BPM, 2BTR, 2BTS, 2C4G, 2C5N, 2C5O, 2C5V, 2C5X, 2C5Y, 2C68, 2C69, 2C6I, 2C6K, 2C6L, 2C6M, 2C6O, 2C6T, 2CCH, 2CCI, 2CJM, 2CLX, 2DS1, 2DUV, 2EXM, 2FVD, 2G9X, 2I40, 2IW6, 2IW8, 2IW9, 2J9M, 2JGZ, 2R3F, 2R3G, 2R3H, 2R3I, 2R3J, 2R3K, 2R3L, 2R3M, 2R3N, 2R3O, 2R3P, 2R3Q, 2R3R, 2R64, 2UUE, 2UZB, 2UZD, 2UZE, 2UZL, 2UZN, 2UZO, 2V0D, 2V22, 2VTA, 2VTH, 2VTI, 2VTJ, 2VTL, 2VTM, 2VTN, 2VTO, 2VTP, 2VTQ, 2VTR, 2VTS, 2VTT, 2VU3, 2VV9, 2W05, 2W06, 2W17, 2W1H, 2WEV, 2WFY, 2WHB, 2WIH, 2WIP, 2WMA, 2WMB, 2WPA, 2WXV, 2X1N, 2XMY, 2XNB, 3BHT, 3BHU, 3BHV, 3DDP, 3DDQ, 3DOG, 3EID, 3EJ1, 3EOC, 3EZR, 3EZV, 3F5X, 3FZ1, 3IG7, 3IGG, 3LE6, 3LFN, 3LFQ, 3LFS, 3MY5, 3NS9, 3PJ8, 3PXF, 3PXQ, 3PXR, 3PXY, 3PXZ, 3PY0, 3PY1, 3QHR, 3QHW, 3QL8, 3QQF, 3QQG, 3QQH, 3QQJ, 3QQK, 3QQL, 3QRT, 3QRU, 3QTQ, 3QTR, 3QTS, 3QTU, 3QTW, 3QTX, 3QTZ, 3QU0, 3QWJ, 3QWK, 3QX2, 3QX4, 3QXO, 3QXP, 3QZF, 3QZG, 3QZH, 3QZI, 3R1Q, 3R1S, 3R1Y, 3R28, 3R6X, 3R71, 3R73, 3R7E, 3R7I, 3R7U, 3R7V, 3R7Y, 3R83, 3R8L, 3R8M, 3R8P, 3R8U, 3R8V, 3R8Z, 3R9D, 3R9H, 3R9N, 3R9O, 3RAH, 3RAI, 3RAK, 3RAL, 3RJC, 3RK5, 3RK7, 3RK9, 3RKB, 3RM6, 3RM7, 3RMF, 3RNI, 3ROY, 3RPO, 3RPR, 3RPV, 3RPY, 3RZB, 3S00, 3S0O, 3S1H, 3S2P, 3SQQ, 3SW4, 3SW7, 3TI1, 3TIY, 3TIZ, 3TNW, 3ULI, 3UNJ, 3UNK, 4ACM, 4BCK, 4BCM, 4BCN, 4BCO, 4BCP, 4BCQ, 4BGH, 4EK3, 4EK4, 4EK5, 4EK6, 4EK8, 4EOI, 4EOJ, 4EOK, 4EOL, 4EOM, 4EON, 4EOO, 4EOP, 4EOQ, 4EOR, 4EOS, 4ERW, 4EZ3, 4EZ7, 4FKG, 4FKI, 4FKJ, 4FKL, 4FKO, 4FKP, 4FKQ, 4FKR, 4FKS, 4FKT, 4FKU, 4FKV, 4FKW, 4FX3, 4GCJ, 4I3Z, 4II5, 3WBL, 4BZD, 4CFM, 4CFN, 4CFU, 4CFV, 4CFW, 4CFX, 4D1X, 4D1Z, 4KD1, 4LYN, 4NJ3, 4RJ3, 5A14, 5CYI, 5D1J, 5FP6, 5FP5, 5K4J, 5IF1, 5AND, 5ANG, 5ANI, 5ANK, 5ANE, 5IEX, 5IEV, 5ANJ, 5ANO, 5IEY
Dynodwyr
Cyfenwau	CDK2, cyclin-dependent kinase 2, A630093N05Rik, CDKN2, p33(CDK2), cyclin dependent kinase 2
Dynodwyr allanol	OMIM: 116953 HomoloGene: 74409 GeneCards: CDK2
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • protein kinase activity; • nucleotide binding; • cyclin-dependent protein serine/threonine kinase activity; • histone kinase activity; • metal ion binding; • GO:0001948, GO:0016582 protein binding; • ATP binding; • kinase activity; • protein serine/threonine kinase activity; • cyclin binding; • cyclin-dependent protein kinase activity; • protein domain specific binding; • magnesium ion binding;
Cydrannau o'r gell	• cytoplasm; • endosome; • Cajal body; • cyclin-dependent protein kinase holoenzyme complex; • transcription regulator complex; • X chromosome; • Y chromosome; • microtubule organizing center; • telomere; • Cytosgerbwd; • condensed chromosome; • cnewyllyn cell; • cytosol; • cyclin A1-CDK2 complex; • cyclin A2-CDK2 complex; • cyclin E1-CDK2 complex; • cyclin E2-CDK2 complex; • nucleoplasm; • centrosome;
Prosesau biolegol	• DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; • phosphorylation; • centrosome duplication; • cellular response to DNA damage stimulus; • Cellraniad; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • DNA replication; • potassium ion transport; • G2/M transition of mitotic cell cycle; • positive regulation of DNA-dependent DNA replication initiation; • GO:0035404 peptidyl-serine phosphorylation; • mitotic G1 DNA damage checkpoint signaling; • cell cycle; • cellular response to nitric oxide; • Ras protein signal transduction; • centriole replication; • regulation of signal transduction by p53 class mediator; • GO:0100026 DNA repair; • GO:1901227 negative regulation of transcription by RNA polymerase II; • multicellular organism development; • positive regulation of cell population proliferation; • response to organic substance; • regulation of G2/M transition of mitotic cell cycle; • protein phosphorylation; • GO:0007126 Meiosis; • G1/S transition of mitotic cell cycle; • anaphase-promoting complex-dependent catabolic process;
	Sources:Amigo / QuickGO
Orthologau
	1017
	n/a
	ENSG00000123374
	n/a
	P24941
	n/a
	NM_001290230; NM_001798; NM_052827
	n/a
	NP_001277159; NP_001789; NP_439892
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CDK2 yw CDK2 a elwir hefyd yn Cyclin dependent kinase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q13.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CDK2.

CDKN2
p33(CDK2)

Llyfryddiaeth

"Molecular Dynamics Simulations and Classical Multidimensional Scaling Unveil New Metastable States in the Conformational Landscape of CDK2. ". PLoS One. 2016. PMID 27100206.
"Cyclin-dependent kinase 2 protects podocytes from apoptosis. ". Sci Rep. 2016. PMID 26876672.
"Formula G1: Cell cycle in the driver's seat of stem cell fate determination. ". Bioessays. 2016. PMID 26857166.
"Hypo/unmethylated promoter status of Cdk2 gene correlates with its over-expression in ovarian cancer in north Indian population. ". Cell Mol Biol (Noisy-le-grand). 2016. PMID 26828990.
"In Silico Identification and In Vitro and In Vivo Validation of Anti-Psychotic Drug Fluspirilene as a Potential CDK2 Inhibitor and a Candidate Anti-Cancer Drug.". PLoS One. 2015. PMID 26147897.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CDK2 - Cronfa NCBI

[1]

[2]