CDK7

CDK7
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1UA2
Dynodwyr
Cyfenwau	CDK7, CAK1, CDKN7, HCAK, MO15, STK1, p39MO15, CAK, cyclin-dependent kinase 7, cyclin dependent kinase 7
Dynodwyr allanol	OMIM: 601955 HomoloGene: 1363 GeneCards: CDK7
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • protein kinase activity; • nucleotide binding; • ATP-dependent activity, acting on DNA; • GO:0001105 transcription coactivator activity; • protein C-terminus binding; • GO:0001948, GO:0016582 protein binding; • androgen receptor binding; • RNA polymerase II CTD heptapeptide repeat kinase activity; • ATP binding; • kinase activity; • protein serine/threonine kinase activity; • cyclin-dependent protein serine/threonine kinase activity;
Cydrannau o'r gell	• nucleoplasm; • perinuclear region of cytoplasm; • cnewyllyn cell; • cytoplasm; • cyclin-dependent protein kinase activating kinase holoenzyme complex; • transcription factor TFIIH holo complex; • transcription factor TFIIK complex;
Prosesau biolegol	• termination of RNA polymerase I transcription; • androgen receptor signaling pathway; • regulation of cyclin-dependent protein serine/threonine kinase activity; • GO:0009373 regulation of transcription, DNA-templated; • phosphorylation; • transcription initiation from RNA polymerase I promoter; • transcription elongation from RNA polymerase II promoter; • 7-methylguanosine mRNA capping; • transcription by RNA polymerase II; • transcription, DNA-templated; • cellular response to DNA damage stimulus; • Cellraniad; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • protein phosphorylation; • cell cycle; • transcription-coupled nucleotide-excision repair; • transcription initiation from RNA polymerase II promoter; • cell population proliferation; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • snRNA transcription by RNA polymerase II; • nucleotide-excision repair, preincision complex assembly; • GO:0100026 DNA repair; • protein stabilization; • G1/S transition of mitotic cell cycle; • G2/M transition of mitotic cell cycle; • GO:0001183 transcription elongation from RNA polymerase I promoter;
	Sources:Amigo / QuickGO
Orthologau
	1022
	n/a
	ENSG00000134058; ENSG00000277273
	n/a
	P50613
	n/a
NM_001799; NM_001324069; NM_001324070; NM_001324071; NM_001324072;
	NM_001324074; NM_001324075; NM_001324077; NM_001324078
	n/a
NP_001310998; NP_001310999; NP_001311000; NP_001311001; NP_001311003;
	NP_001311004; NP_001311006; NP_001311007; NP_001790
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CDK7 yw CDK7 a elwir hefyd yn Cyclin dependent kinase 7 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5q13.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CDK7.

CAK
CAK1
HCAK
MO15
STK1
CDKN7
p39MO15

Llyfryddiaeth

"Upregulation of CDK7 in gastric cancer cell promotes tumor cell proliferation and predicts poor prognosis. ". Exp Mol Pathol. 2016. PMID 27155449.
"CDK7-dependent transcriptional addiction in triple-negative breast cancer. ". Cell. 2015. PMID 26406377.
"THZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping and Pausing. ". Mol Cell. 2015. PMID 26257281.
"Cyclin-dependent kinase 7 controls mRNA synthesis by affecting stability of preinitiation complexes, leading to altered gene expression, cell cycle progression, and survival of tumor cells. ". Mol Cell Biol. 2014. PMID 25047832.
"Human and Xenopus mo15 messenger-RNA are highly conserved but show different patterns of expression in adult tissues.". Oncol Rep. 1994. PMID 21607529.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CDK7 - Cronfa NCBI

[1]

[2]