CDKN1B

CDKN1B
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2AST, 1H27, 1JSU
Dynodwyr
Cyfenwau	CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1, cyclin-dependent kinase inhibitor 1B, cyclin dependent kinase inhibitor 1B
Dynodwyr allanol	OMIM: 600778 HomoloGene: 2999 GeneCards: CDKN1B
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001948, GO:0016582 protein binding; • protein phosphatase binding; • cyclin-dependent protein serine/threonine kinase activity; • protein kinase inhibitor activity; • protein kinase binding; • cyclin binding; • cyclin-dependent protein serine/threonine kinase inhibitor activity; • Hsp70 protein binding; • GO:0032403 protein-containing complex binding; • chaperone binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • endosome; • nucleoplasm; • Cul4A-RING E3 ubiquitin ligase complex; • cnewyllyn cell; • intracellular membrane-bounded organelle; • GO:0009327 protein-containing complex;
Prosesau biolegol	• Notch signaling pathway; • regulation of cyclin-dependent protein serine/threonine kinase activity; • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; • response to estradiol; • positive regulation of cell death; • response to hypoxia; • response to amino acid; • response to cadmium ion; • GO:1903364 positive regulation of protein catabolic process; • GO:1904578 response to organic cyclic compound; • cellular response to lithium ion; • GO:1904579 cellular response to organic cyclic compound; • response to peptide hormone; • marwolaeth celloedd; • negative regulation of apoptotic process; • Q14865145; • response to glucose; • potassium ion transport; • regulation of cell population proliferation; • negative regulation of cell growth; • negative regulation of epithelial cell proliferation involved in prostate gland development; • positive regulation of cell population proliferation; • positive regulation of cyclin-dependent protein serine/threonine kinase activity; • negative regulation of epithelial cell proliferation; • positive regulation of microtubule polymerization; • inner ear development; • GO:1904577 cellular response to antibiotic; • cell cycle; • negative regulation of phosphorylation; • GO:0045996 negative regulation of transcription, DNA-templated; • autophagic cell death; • negative regulation of cell population proliferation; • negative regulation of mitotic cell cycle; • negative regulation of kinase activity; • positive regulation of cell cycle; • negative regulation of vascular associated smooth muscle cell proliferation; • placenta development; • regulation of exit from mitosis; • regulation of lens fiber cell differentiation; • negative regulation of cyclin-dependent protein kinase activity; • negative regulation of cell cycle; • negative regulation of cyclin-dependent protein serine/threonine kinase activity; • G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologau
	1027
	n/a
	ENSG00000111276
	n/a
	P46527
	n/a
	NM_004064
	n/a
	NP_004055
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CDKN1B yw CDKN1B a elwir hefyd yn Cyclin dependent kinase inhibitor 1B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12p13.1.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CDKN1B.

KIP1
MEN4
CDKN4
MEN1B
P27KIP1

Llyfryddiaeth[golygu | golygu cod]

"p27 Is a Candidate Prognostic Biomarker and Metastatic Promoter in Osteosarcoma. ". Cancer Res. 2016. PMID 27197201.
"Cryptic sequence features within the disordered protein p27Kip1 regulate cell cycle signaling. ". Proc Natl Acad Sci U S A. 2016. PMID 27140628.
"Cyclins A, B, E and p27 in Endometrial Endometrioid Adenocarcinoma. ". Anticancer Res. 2016. PMID 27919969.
"P27/CDKN1B Translational Regulators in Pituitary Tumorigenesis. ". Horm Metab Res. 2016. PMID 27824399.
"Rewiring of the apoptotic TGF-β-SMAD/NFκB pathway through an oncogenic function of p27 in human papillary thyroid cancer.". Oncogene. 2017. PMID 27452523.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] CDKN1B - Cronfa NCBI

[1]

[2]