CDKN2A

CDKN2A
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2A5E, 1A5E, 1BI7, 1DC2,%%s1A5E, 1BI7, 1DC2, 2A5E
Dynodwyr
Cyfenwau	CDKN2A, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16, cyclin-dependent kinase inhibitor 2A, cyclin dependent kinase inhibitor 2A, Genes, p16, ARF.
Dynodwyr allanol	OMIM: 600160 HomoloGene: 55430 GeneCards: CDKN2A
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• NF-kappaB binding; • GO:0001948, GO:0016582 protein binding; • cyclin-dependent protein serine/threonine kinase inhibitor activity; • protein kinase binding; • RNA binding; • DNA binding; • p53 binding; • transcription factor binding; • MDM2/MDM4 family protein binding; • ubiquitin-protein transferase inhibitor activity; • SUMO transferase activity; • disordered domain specific binding; • GO:0090645, GO:0061637 ubiquitin ligase inhibitor activity;
Cydrannau o'r gell	• cytoplasm; • cytosol; • senescence-associated heterochromatin focus; • cnewyllyn cell; • nuclear body; • nucleoplasm; • nucleolus; • mitocondria; • GO:0009327 protein-containing complex;
Prosesau biolegol	• positive regulation of smooth muscle cell apoptotic process; • negative regulation of cyclin-dependent protein serine/threonine kinase activity; • replicative senescence; • G1 phase; • negative regulation of cell-matrix adhesion; • cellular senescence; • negative regulation of cell growth; • positive regulation of cellular senescence; • positive regulation of macrophage apoptotic process; • cell cycle; • Ras protein signal transduction; • negative regulation of phosphorylation; • GO:0045996 negative regulation of transcription, DNA-templated; • negative regulation of NF-kappaB transcription factor activity; • negative regulation of cell population proliferation; • G1/S transition of mitotic cell cycle; • GO:1990376 negative regulation of G1/S transition of mitotic cell cycle; • GO:0097285 apoptotic process; • regulation of G2/M transition of mitotic cell cycle; • GO:0009373 regulation of transcription, DNA-templated; • regulation of protein stability; • negative regulation of immature T cell proliferation in thymus; • regulation of protein export from nucleus; • negative regulation of protein kinase activity; • negative regulation of proteolysis involved in cellular protein catabolic process; • protein K63-linked ubiquitination; • positive regulation of signal transduction by p53 class mediator; • somatic stem cell division; • protein stabilization; • protein polyubiquitination; • positive regulation of protein sumoylation; • transcription, DNA-templated; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • autophagy of mitochondrion; • apoptotic mitochondrial changes; • regulation of protein targeting to mitochondrion; • protein destabilization; • negative regulation of ubiquitin-protein transferase activity; • positive regulation of apoptotic process; • rRNA processing; • negative regulation of ubiquitin-dependent protein catabolic process; • mitochondrial depolarization; • positive regulation of DNA damage response, signal transduction by p53 class mediator; • negative regulation of B cell proliferation; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • regulation of apoptotic DNA fragmentation; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • positive regulation of protein localization to nucleus; • protein sumoylation; • GO:1901313 positive regulation of gene expression; • GO:0060564, GO:1904190 negative regulation of ubiquitin protein ligase activity; • amyloid fibril formation; • negative regulation of protein neddylation;
	Sources:Amigo / QuickGO
Orthologau
	1029
	n/a
	ENSG00000147889
	n/a
	P42771; Q8N726
	n/a
NM_000077; NM_001195132; NM_058195; NM_058196; NM_058197;
	NM_001363763
	n/a
NP_000068; NP_001182061; NP_478102; NP_478104; NP_001350692;
	NP_478102.2
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CDKN2A yw CDKN2A a elwir hefyd yn Tumor suppressor ARF (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 9, band 9p21.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CDKN2A.

ARF
MLM
P14
P16
P19
CMM2
INK4
MTS1
TP16
CDK4I
CDKN2
INK4A
MTS-1
P14ARF
P19ARF
P16INK4
P16INK4A
P16-INK4A

Llyfryddiaeth

"Utility of p16 Immunohistochemistry in Evaluating Negative Cervical Biopsies Following High-risk Pap Test Results. ". Am J Surg Pathol. 2018. PMID 29112019.
"Germline Variation at CDKN2A and Associations with Nevus Phenotypes among Members of Melanoma Families. ". J Invest Dermatol. 2017. PMID 28830827.
"Cancer risks and survival in patients with multiple primary melanomas: Association with family history of melanoma and germline CDKN2A mutation status. ". J Am Acad Dermatol. 2017. PMID 28818438.
"Using p16 immunohistochemistry to classify morphologic cervical intraepithelial neoplasia 2: correlation of ambiguous staining patterns with HPV subtypes and clinical outcome. ". Hum Pathol. 2017. PMID 28705710.
"Obesity and Downregulation Activate Breast Adipocytes and Promote Their Protumorigenicity.". Mol Cell Biol. 2017. PMID 28630279.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CDKN2A - Cronfa NCBI

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[2]