CDKN2C

CDKN2C
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1BU9, 1G3N, 1IHB, 1MX2, 1MX4, 1MX6
Dynodwyr
Cyfenwau	CDKN2C, INK4C, p18, p18-INK4C, cyclin-dependent kinase inhibitor 2C, cyclin dependent kinase inhibitor 2C
Dynodwyr allanol	OMIM: 603369 HomoloGene: 966 GeneCards: CDKN2C
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001948, GO:0016582 protein binding; • cyclin-dependent protein serine/threonine kinase inhibitor activity; • protein kinase binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • cnewyllyn cell;
Prosesau biolegol	• cell cycle; • regulation of cyclin-dependent protein serine/threonine kinase activity; • oligodendrocyte differentiation; • negative regulation of phosphorylation; • negative regulation of cell growth; • negative regulation of cell population proliferation; • negative regulation of cyclin-dependent protein serine/threonine kinase activity; • G1/S transition of mitotic cell cycle; • GO:1990376 negative regulation of G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologau
	1031
	n/a
	ENSG00000123080
	n/a
	P42773
	n/a
	NM_078626; NM_001262
	n/a
	NP_001253; NP_523240
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CDKN2C yw CDKN2C a elwir hefyd yn Cyclin dependent kinase inhibitor 2C (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p32.3.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CDKN2C.

p18
INK4C
p18-INK4C

Llyfryddiaeth[golygu | golygu cod]

"Repression of CDKN2C caused by PML/RARα binding promotes the proliferation and differentiation block in acute promyelocytic leukemia. ". Front Med. 2016. PMID 27888400.
"Array-CGH predicts prognosis in plasma cell post-transplantation lymphoproliferative disorders. ". Genes Chromosomes Cancer. 2017. PMID 27750397.
"Expression levels of p18INK4C modify the cellular efficacy of cyclin-dependent kinase inhibitors via regulation of Mcl-1 expression in tumor cell lines. ". Mol Cancer Ther. 2009. PMID 19509251.
"Expression of p18(INK4C) is down-regulated in human pituitary adenomas. ". Endocr Pathol. 2009. PMID 19401813.
"Frequent loss of the CDKN2C (p18INK4c) gene product in pituitary adenomas.". Genes Chromosomes Cancer. 2009. PMID 18973139.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] CDKN2C - Cronfa NCBI

[1]

[2]