CDKN3

CDKN3
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1FPZ, 1FQ1
Dynodwyr
Cyfenwau	CDKN3, CDI1, CIP2, KAP, KAP1, cyclin-dependent kinase inhibitor 3, cyclin dependent kinase inhibitor 3, CDLN3
Dynodwyr allanol	OMIM: 123832 HomoloGene: 3805 GeneCards: CDKN3
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0098519, GO:0098518 phosphatase activity; • protein serine/threonine phosphatase activity; • phosphoprotein phosphatase activity; • hydrolase activity; • GO:0001948, GO:0016582 protein binding; • protein tyrosine/serine/threonine phosphatase activity; • protein tyrosine phosphatase activity;
Cydrannau o'r gell	• cnewyllyn cell; • perinuclear region of cytoplasm; • cytoplasm; • cytosol;
Prosesau biolegol	• cell cycle; • regulation of cyclin-dependent protein serine/threonine kinase activity; • negative regulation of cell population proliferation; • GO:0098501, GO:0098502, GO:0006286 dephosphorylation; • peptidyl-tyrosine dephosphorylation; • GO:0016576 protein dephosphorylation; • G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologau
	1033
	n/a
	ENSG00000100526
	n/a
	Q16667
	n/a
	NM_001130851; NM_005192; NM_001330173
	n/a
	NP_001124323; NP_001317102; NP_005183
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CDKN3 yw CDKN3 a elwir hefyd yn Cyclin dependent kinase inhibitor 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q22.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CDKN3.

KAP
CDI1
CIP2
KAP1

Llyfryddiaeth

"Expression and alternative splicing of the cyclin-dependent kinase inhibitor-3 gene in human cancer. ". Int J Biochem Cell Biol. 2017. PMID 28504190.
"Knockdown of Cyclin-Dependent Kinase Inhibitor 3 Inhibits Proliferation and Invasion in Human Gastric Cancer Cells. ". Oncol Res. 2017. PMID 27983933.
"Silencing cyclin-dependent kinase inhibitor 3 inhibits the migration of breast cancer cell lines. ". Mol Med Rep. 2016. PMID 27314680.
"CDKN3 expression is negatively associated with pathological tumor stage and CDKN3 inhibition promotes cell survival in hepatocellular carcinoma. ". Mol Med Rep. 2016. PMID 27314282.
"Overexpression of major CDKN3 transcripts is associated with poor survival in lung adenocarcinoma.". Br J Cancer. 2015. PMID 26554648.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CDKN3 - Cronfa NCBI

[1]

[2]