CEBPB

CEBPB
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1GTW, 1GU4, 1GU5, 1H88, 1H89, 1H8A, 1HJB, 1IO4, 2E42, 2E43
Dynodwyr
Cyfenwau	CEBPB, C/EBP-beta, IL6DBP, NF-IL6, TCF5, CCAAT/enhancer binding protein beta, CCAAT enhancer binding protein beta
Dynodwyr allanol	OMIM: 189965 HomoloGene: 3807 GeneCards: CEBPB
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • sequence-specific DNA binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • protein homodimerization activity; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • transcription factor binding; • histone deacetylase binding; • chromatin binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • kinase binding; • GO:0001948, GO:0016582 protein binding; • histone acetyltransferase binding; • ubiquitin-like protein ligase binding; • protein heterodimerization activity; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • RNA polymerase II core promoter sequence-specific DNA binding; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • glucocorticoid receptor binding;
Cydrannau o'r gell	• cytoplasm; • nuclear matrix; • CHOP-C/EBP complex; • nucleoplasm; • cnewyllyn cell; • condensed chromosome, centromeric region; • RNA polymerase II transcription regulator complex;
Prosesau biolegol	• GO:1904089 negative regulation of neuron apoptotic process; • mammary gland epithelial cell proliferation; • cell differentiation; • GO:0009373 regulation of transcription, DNA-templated; • positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; • GO:1904579 cellular response to organic cyclic compound; • embryonic placenta development; • Cof; • positive regulation of interleukin-4 production; • response to endoplasmic reticulum stress; • mammary gland epithelial cell differentiation; • transcription, DNA-templated; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • negative regulation of T cell proliferation; • liver regeneration; • positive regulation of osteoblast differentiation; • hepatocyte proliferation; • response to lipopolysaccharide; • regulation of osteoclast differentiation; • defense response to bacterium; • acute-phase response; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • neuron differentiation; • cellular response to interleukin-1; • brown fat cell differentiation; • cellular response to amino acid stimulus; • ovarian follicle development; • liver development; • inflammatory response; • GO:0045996 negative regulation of transcription, DNA-templated; • positive regulation of fat cell differentiation; • cellular response to lipopolysaccharide; • fat cell differentiation; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; • transcription by RNA polymerase II; • granuloma formation; • T-helper 1 cell activation; • GO:1901227 negative regulation of transcription by RNA polymerase II; • regulation of odontoblast differentiation; • positive regulation of biomineral tissue development; • positive regulation of sodium-dependent phosphate transport; • positive regulation of inflammatory response; • positive regulation of cold-induced thermogenesis; • regulation of dendritic cell differentiation;
	Sources:Amigo / QuickGO
Orthologau
	1051
	n/a
	ENSG00000172216
	n/a
	P17676
	n/a
	NM_005194; NM_001285878; NM_001285879
	n/a
	NP_001272807; NP_001272808; NP_005185
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CEBPB yw CEBPB a elwir hefyd yn CCAAT/enhancer binding protein beta (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 20, band 20q13.13.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CEBPB.

TCF5
IL6DBP
NF-IL6
C/EBP-beta

Llyfryddiaeth

"The role of C/EBPβ phosphorylation in modulating membrane phospholipids repairing in LPS-induced human lung/bronchial epithelial cells. ". Gene. 2017. PMID 28760550.
"Exposure to p,p'-DDE Induces Morphological Changes and Activation of the PKCα-p38-C/EBPβPathway in Human Promyelocytic HL-60 Cells. ". Biomed Res Int. 2016. PMID 27833915.
"Staurosporine enhances ATRA-induced granulocytic differentiation in human leukemia U937 cells via the MEK/ERK signaling pathway. ". Oncol Rep. 2016. PMID 27665842.
"C/EBPβ-Thr217 Phosphorylation Stimulates Macrophage Inflammasome Activation and Liver Injury. ". Sci Rep. 2016. PMID 27067260.
"C/EBP β Mediates Endoplasmic Reticulum Stress Regulated Inflammatory Response and Extracellular Matrix Degradation in LPS-Stimulated Human Periodontal Ligament Cells.". Int J Mol Sci. 2016. PMID 27011164.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CEBPB - Cronfa NCBI

[1]

[2]