CELF1

CELF1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2CPZ, 2DHS, 2RQ4, 2RQC, 3NMR, 3NNA, 3NNC, 3NNH
Dynodwyr
Cyfenwau	CELF1, BRUNOL2, CUG-BP, CUGBP, CUGBP1, EDEN-BP, NAB50, NAPOR, hNab50, CUGBP, Elav-like family member 1, CUGBP Elav-like family member 1
Dynodwyr allanol	OMIM: 601074 HomoloGene: 136342 GeneCards: CELF1
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• translation repressor activity, mRNA regulatory element binding; • GO:0001948, GO:0016582 protein binding; • RNA binding; • nucleic acid binding; • BRE binding; • mRNA binding; • pre-mRNA binding;
Cydrannau o'r gell	• cytoplasm; • bilen; • nucleoplasm; • cnewyllyn cell; • ribonucleoprotein complex;
Prosesau biolegol	• germ cell development; • embryo development; • mRNA processing; • GO:0035194 RNA interference; • regulation of RNA splicing; • RNA splicing; • negative regulation of translation; • mRNA splice site selection; • regulation of alternative mRNA splicing, via spliceosome; • embryo development ending in birth or egg hatching;
	Sources:Amigo / QuickGO
Orthologau
	10658
	n/a
	ENSG00000149187
	n/a
	Q92879
	n/a
NM_001025596; NM_001172639; NM_001172640; NM_006560; NM_198700;
	NM_001330272
	n/a
NP_001020767; NP_001166110; NP_001166111; NP_001317201; NP_006551;
	NP_941989; NP_001363298; NP_001363299; NP_001363300; NP_001363301; NP_001363302; NP_001363303; NP_001363305; NP_001363306; NP_001363307; NP_001363308; NP_001363309; NP_001363310; NP_001363311; NP_001363312; NP_001363313; NP_001363314; NP_001363315; NP_001363316; NP_001363317; NP_001363318; NP_001363319; NP_001363320; NP_001363322; NP_001363324; NP_001363325; NP_001363326; NP_001363328; NP_001363335; NP_001363336; NP_001363337; NP_001363338; NP_001363339; NP_001363340; NP_001363341; NP_001363342; NP_001363343; NP_001363344; NP_001363346; NP_001363347; NP_001363348; NP_001363349; NP_001363350; NP_001363351; NP_001363352; NP_001363353; NP_001363354; NP_001363355; NP_001363356; NP_001363357; NP_001363358; NP_001363359; NP_001363360; NP_001363361; NP_001363362; NP_001363363; NP_001363364; NP_001363365; NP_001363366; NP_001363367; NP_001363368; NP_001363369; NP_001363370; NP_001363371; NP_001363372; NP_001363373; NP_001363374; NP_001363375; NP_001363376; NP_001363377; NP_001363378; NP_001363379; NP_001363380; NP_001363381; NP_001363382; NP_001363383; NP_001363384; NP_001363385; NP_001363386; NP_001363387; NP_001363388; NP_001363389; NP_001363390; NP_001363391; NP_001363392; NP_001363304
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CELF1 yw CELF1 a elwir hefyd yn CUGBP Elav-like family member 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p11.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CELF1.

CUGBP
NAB50
NAPOR
CUG-BP
CUGBP1
hNab50
BRUNOL2
EDEN-BP

Llyfryddiaeth

"RNA-binding protein CELF1 promotes tumor growth and alters gene expression in oral squamous cell carcinoma. ". Oncotarget. 2015. PMID 26498364.
"Altered CELF1 binding to target transcripts in malignant T cells. ". RNA. 2015. PMID 26249002.
"CELF1 preferentially binds to exon-intron boundary and regulates alternative splicing in HeLa cells. ". Biochim Biophys Acta. 2017. PMID 28733224.
"CUG-binding protein 1 regulates HSC activation and liver fibrogenesis. ". Nat Commun. 2016. PMID 27853137.
"Prognostic impact of CUG-binding protein 1 expression and vascular invasion after radical surgery for stage IB nonsmall cell lung cancer.". Indian J Cancer. 2015. PMID 26728670.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CELF1 - Cronfa NCBI

[1]

[2]