CENPE

CENPE
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1T5C
Dynodwyr
Cyfenwau	CENPE, CENP-E, KIF10, PPP1R61, MCPH13, Centromere protein E
Dynodwyr allanol	OMIM: 117143 HomoloGene: 20429 GeneCards: CENPE
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nucleotide binding; • ATPase activity; • ATP binding; • GO:0001948, GO:0016582 protein binding; • microtubule motor activity; • microtubule binding; • kinetochore binding;
Cydrannau o'r gell	• spindle; • kinesin complex; • Cromosom; • cnewyllyn cell; • outer kinetochore; • chromosome, centromeric region; • bilen; • midbody; • microtubule; • kinetochore; • condensed chromosome, centromeric region; • microtubule cytoskeleton; • mitotic spindle midzone; • Cytosgerbwd; • cytoplasm; • cytosol; • kinetochore microtubule; • nucleoplasm; • spindle midzone;
Prosesau biolegol	• regulation of mitotic metaphase/anaphase transition; • cell cycle; • positive regulation of protein kinase activity; • multicellular organism development; • Cellraniad; • antigen processing and presentation of exogenous peptide antigen via MHC class II; • kinetochore assembly; • microtubule-based movement; • sister chromatid cohesion; • retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; • metaphase plate congression; • lateral attachment of mitotic spindle microtubules to kinetochore; • GO:0007067 Mitosis; • GO:0043148 mitotic spindle organization; • mitotic chromosome movement towards spindle pole; • microtubule plus-end directed mitotic chromosome migration; • chromosome segregation; • mitotic metaphase plate congression; • attachment of mitotic spindle microtubules to kinetochore;
	Sources:Amigo / QuickGO
Orthologau
	1062
	n/a
	ENSG00000138778
	n/a
	Q02224
	n/a
	NM_001286734; NM_001813
	n/a
	NP_001273663; NP_001804
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CENPE yw CENPE a elwir hefyd yn Centromere protein E (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4q24.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CENPE.

KIF10
CENP-E
MCPH13
PPP1R61

Llyfryddiaeth[golygu | golygu cod]

"Kinetochore motors drive congression of peripheral polar chromosomes by overcoming random arm-ejection forces. ". Nat Cell Biol. 2014. PMID 25383660.
"Chemogenetic evaluation of the mitotic kinesin CENP-E reveals a critical role in triple-negative breast cancer. ". Mol Cancer Ther. 2014. PMID 24928852.
"Kinetochore-microtubule attachment throughout mitosis potentiated by the elongated stalk of the kinetochore kinesin CENP-E. ". Mol Biol Cell. 2014. PMID 24920822.
"Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips. ". Nat Cell Biol. 2013. PMID 23955301.
"Evolution driven structural changes in CENP-E motor domain.". Interdiscip Sci. 2013. PMID 23740391.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] CENPE - Cronfa NCBI

[1]

[2]