CHD5

CHD5
Dynodwyr
Cyfenwau	CHD5, CHD-5, chromodomain helicase DNA binding protein 5, PMNDS
Dynodwyr allanol	OMIM: 610771 HomoloGene: 56712 GeneCards: CHD5
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • nucleotide binding; • GO:0008026 helicase activity; • metal ion binding; • H3K27me3 modified histone binding; • hydrolase activity; • ATP binding;
Cydrannau o'r gell	• NuRD complex; • bilen; • GO:0035328 heterochromatin; • cnewyllyn cell; • nucleoplasm; • cytosol; • nuclear speck;
Prosesau biolegol	• cell differentiation; • GO:0009373 regulation of transcription, DNA-templated; • histone H3-K27 trimethylation; • positive regulation of signal transduction by p53 class mediator; • transcription, DNA-templated; • nervous system development; • spermatogenesis; • histone H4 acetylation; • cerebral cortex neuron differentiation; • negative regulation of cell population proliferation; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization;
	Sources:Amigo / QuickGO
Orthologau
	26038
	n/a
	ENSG00000116254
	n/a
	Q8TDI0
	n/a
	NM_015557
	n/a
	NP_056372
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CHD5 yw CHD5 a elwir hefyd yn Chromodomain-helicase-DNA-binding protein 5 a Chromodomain helicase DNA binding protein 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p36.31.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CHD5.

CHD-5

Llyfryddiaeth

"The tumor suppressor chromodomain helicase DNA-binding protein 5 (CHD5) remodels nucleosomes by unwrapping. ". J Biol Chem. 2014. PMID 24923445.
"CHD5 a tumour suppressor is epigenetically silenced in hepatocellular carcinoma. ". Liver Int. 2014. PMID 24529164.
"CHD5 is a potential tumor suppressor in non small cell lung cancer (NSCLC). ". Gene. 2017. PMID 28400267.
"The epigenetic modifier CHD5 functions as a novel tumor suppressor for renal cell carcinoma and is predominantly inactivated by promoter CpG methylation. ". Oncotarget. 2016. PMID 26943038.
"Influence of colorectal cancer tumor suppressor gene CHD5 methylation on its clinical and pathological characteristics.". J Biol Regul Homeost Agents. 2015. PMID 26753653.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CHD5 - Cronfa NCBI

[1]

[2]