CHRNA1

CHRNA1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4ZJS
Dynodwyr
Cyfenwau	CHRNA1, ACHRA, ACHRD, CHRNA, CMS2A, FCCMS, SCCMS, CMS1A, CMS1B, Cholinergic receptor, nicotinic, alpha 1, cholinergic receptor nicotinic alpha 1 subunit
Dynodwyr allanol	OMIM: 100690 HomoloGene: 59 GeneCards: CHRNA1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• extracellular ligand-gated ion channel activity; • acetylcholine receptor activity; • ligand-gated ion channel activity; • ion channel activity; • acetylcholine binding; • acetylcholine-gated cation-selective channel activity; • transmembrane signaling receptor activity; • transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cydrannau o'r gell	• integral component of membrane; • bilen; • synapse; • cell junction; • Cellbilen; • neuromuscular junction; • cell surface; • postsynaptic membrane; • acetylcholine-gated channel complex; • integral component of postsynaptic specialization membrane; • integral component of plasma membrane; • neuron projection;
Prosesau biolegol	• muscle cell cellular homeostasis; • neuron cellular homeostasis; • regulation of membrane potential; • skeletal muscle contraction; • response to nicotine; • cation transport; • synaptic transmission, cholinergic; • cludo ïon; • skeletal muscle tissue growth; • neuromuscular synaptic transmission; • neuromuscular process; • neuromuscular junction development; • musculoskeletal movement; • GO:0072468 signal transduction; • neuronal action potential; • regulation of postsynaptic membrane potential; • excitatory postsynaptic potential; • cludo transmembrane rhwng ïonau; • chemical synaptic transmission; • nervous system process;
	Sources:Amigo / QuickGO
Orthologau
	1134
	n/a
	ENSG00000138435
	n/a
	P02708
	n/a
	NM_001039523; NM_000079
	n/a
	NP_000070; NP_001034612
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CHRNA1 yw CHRNA1 a elwir hefyd yn Cholinergic receptor nicotinic alpha 1 subunit (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q31.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CHRNA1.

ACHRA
ACHRD
CHRNA
CMS1A
CMS1B
CMS2A
FCCMS
SCCMS

Llyfryddiaeth

"High Throughput Random Mutagenesis and Single Molecule Real Time Sequencing of the Muscle Nicotinic Acetylcholine Receptor. ". PLoS One. 2016. PMID 27649498.
"Effect of nicotinic acetylcholine receptor alpha 1 (nAChRα1) peptides on rabies virus infection in neuronal cells. ". Neuropeptides. 2016. PMID 26656837.
"Antisense oligonucleotide-mediated exon skipping of CHRNA1 pre-mRNA as potential therapy for Congenital Myasthenic Syndromes. ". Biochem Biophys Res Commun. 2015. PMID 25888793.
"Expression of a highly antigenic and native-like folded extracellular domain of the human α1 subunit of muscle nicotinic acetylcholine receptor, suitable for use in antigen specific therapies for Myasthenia Gravis. ". PLoS One. 2013. PMID 24376846.
"High expression of CHRNA1 is associated with reduced survival in early stage lung adenocarcinoma after complete resection.". Ann Surg Oncol. 2013. PMID 23775407.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CHRNA1 - Cronfa NCBI

[1]

[2]