CITED2

CITED2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1P4Q, 1R8U
Dynodwyr
Cyfenwau	CITED2, ASD8, MRG-1, MRG1, P35SRJ, VSD2, Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2
Dynodwyr allanol	OMIM: 602937 HomoloGene: 4433 GeneCards: CITED2
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001105 transcription coactivator activity; • GO:0001106 transcription corepressor activity; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • chromatin binding; • LBD domain binding; • GO:0001948, GO:0016582 protein binding; • histone acetyltransferase binding; • protein domain specific binding;
Cydrannau o'r gell	• cytoplasm; • cnewyllyn cell; • nucleoplasm; • GO:0009327 protein-containing complex;
Prosesau biolegol	• nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry; • adrenal cortex formation; • positive regulation of transforming growth factor beta receptor signaling pathway; • cell differentiation; • response to hypoxia; • GO:0009373 regulation of transcription, DNA-templated; • positive regulation of cell-cell adhesion; • embryonic heart tube left/right pattern formation; • ventricular septum morphogenesis; • outflow tract morphogenesis; • negative regulation of apoptotic process; • GO:1901227 negative regulation of transcription by RNA polymerase II; • spleen development; • negative regulation of gene expression; • transcription, DNA-templated; • response to fluid shear stress; • response to estrogen; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • multicellular organism development; • heart development; • determination of left/right symmetry; • GO:1901313 positive regulation of gene expression; • negative regulation of cell migration; • positive regulation of cell cycle; • regulation of animal organ formation; • sex-determination system; • positive regulation of peroxisome proliferator activated receptor signaling pathway; • liver development; • left/right pattern formation; • negative regulation of transcription from RNA polymerase II promoter in response to hypoxia; • cell population proliferation; • GO:0045996 negative regulation of transcription, DNA-templated; • left/right axis specification; • positive regulation of male gonad development; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • transcription by RNA polymerase II; • positive regulation of nucleic acid-templated transcription; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologau
	10370
	n/a
	ENSG00000164442
	n/a
	Q99967
	n/a
	NM_006079; NM_001168388; NM_001168389
	n/a
	NP_001161860; NP_001161861; NP_006070
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CITED2 yw CITED2 a elwir hefyd yn Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6q24.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CITED2.

ASD8
MRG1
VSD2
MRG-1
P35SRJ

Llyfryddiaeth

"Downregulation of CITED2 contributes to TGFβ-mediated senescence of tendon-derived stem cells. ". Cell Tissue Res. 2017. PMID 28084522.
"CITED2 in breast carcinoma as a potent prognostic predictor associated with proliferation, migration and chemoresistance. ". Cancer Sci. 2016. PMID 27627783.
"Functional Analyses of a Novel CITED2 Nonsynonymous Mutation in Chinese Tibetan Patients with Congenital Heart Disease. ". Pediatr Cardiol. 2017. PMID 28687891.
"Knockdown of Cbp/P300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 inhibits cell division and increases apoptosis in gastric cancer. ". J Surg Res. 2017. PMID 28501104.
"CITED2 Mutations in Conserved Regions Contribute to Conotruncal Heart Defects in Chinese Children.". DNA Cell Biol. 2017. PMID 28436679.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CITED2 - Cronfa NCBI

[1]

[2]