CLIC4

CLIC4
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2AHE, 2D2Z, 3OQS
Dynodwyr
Cyfenwau	CLIC4, CLIC4L, H1, MTCLIC, huH1, p64H1, chloride intracellular channel 4
Dynodwyr allanol	OMIM: 606536 HomoloGene: 8490 GeneCards: CLIC4
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• voltage-gated ion channel activity; • GO:0001948, GO:0016582 protein binding; • glutathione transferase activity; • chloride channel activity;
Cydrannau o'r gell	• cytoplasm; • integral component of membrane; • cytosol; • centrosome; • bilen; • cell-cell junction; • nuclear matrix; • microtubule cytoskeleton; • Cellbilen; • apical part of cell; • intracellular anatomical structure; • chloride channel complex; • microtubule organizing center; • microvillus; • cell surface; • cell junction; • midbody; • mitocondria; • actin cytoskeleton; • perinuclear region of cytoplasm; • extracellular exosome; • Cytosgerbwd; • cytoplasmic vesicle membrane; • GO:0016023 cytoplasmic vesicle; • cnewyllyn cell;
Prosesau biolegol	• cellular response to calcium ion; • cell differentiation; • multicellular organism growth; • regulation of ion transmembrane transport; • endothelial cell morphogenesis; • cludo ïon; • keratinocyte differentiation; • vacuolar acidification; • negative regulation of cell migration; • fertilization; • establishment or maintenance of apical/basal cell polarity; • chloride transport; • branching morphogenesis of an epithelial tube; • retina vasculature morphogenesis in camera-type eye; • regulation of cytoskeleton organization; • angiogenesis; • glutathione metabolic process; • chloride transmembrane transport; • GO:0015915 transport; • cludo transmembrane rhwng ïonau;
	Sources:Amigo / QuickGO
Orthologau
	25932
	n/a
	ENSG00000169504
	n/a
	Q9Y696
	n/a
	NM_013943
	n/a
	NP_039234
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CLIC4 yw CLIC4 a elwir hefyd yn Chloride intracellular channel 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p36.11.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CLIC4.

H1
huH1
p64H1
CLIC4L
MTCLIC

Llyfryddiaeth

"CLIC4 is a tumor suppressor for cutaneous squamous cell cancer. ". Carcinogenesis. 2012. PMID 22387366.
"CLIC4 mediates TGF-beta1-induced fibroblast-to-myofibroblast transdifferentiation in ovarian cancer. ". Oncol Rep. 2009. PMID 19639201.
"CLIC4 regulates TGF-β-dependent myofibroblast differentiation to produce a cancer stroma. ". Oncogene. 2014. PMID 23416981.
"Suppression of CLIC4/mtCLIC enhances hydrogen peroxide-induced apoptosis in C6 glioma cells. ". Oncol Rep. 2013. PMID 23380911.
"Inhibition of CLIC4 enhances autophagy and triggers mitochondrial and ER stress-induced apoptosis in human glioma U251 cells under starvation.". PLoS One. 2012. PMID 22761775.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CLIC4 - Cronfa NCBI

[1]

[2]