CLK1

CLK1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1Z57, 2VAG, 5J1V, 5J1W
Dynodwyr
Cyfenwau	CLK1, CLK, CLK/STY, STY, CDC like kinase 1
Dynodwyr allanol	OMIM: 601951 HomoloGene: 101535 GeneCards: CLK1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • nucleotide binding; • protein serine/threonine/tyrosine kinase activity; • protein serine/threonine kinase activity; • protein kinase activity; • protein tyrosine kinase activity; • non-membrane spanning protein tyrosine kinase activity; • GO:0001948, GO:0016582 protein binding; • ATP binding; • kinase activity;
Cydrannau o'r gell	• cytoplasm; • cnewyllyn cell;
Prosesau biolegol	• protein autophosphorylation; • peptidyl-tyrosine phosphorylation; • regulation of RNA splicing; • protein phosphorylation; • cell population proliferation; • peptidyl-threonine phosphorylation; • GO:0035404 peptidyl-serine phosphorylation; • phosphorylation;
	Sources:Amigo / QuickGO
Orthologau
	1195
	n/a
	ENSG00000013441
	n/a
	P49759
	n/a
	NM_001024646; NM_001162407; NM_004071
	n/a
	NP_001155879; NP_004062
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CLK1 yw CLK1 a elwir hefyd yn CDC like kinase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q33.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CLK1.

CLK
STY
CLK/STY

Llyfryddiaeth

"Clk1-regulated aerobic glycolysis is involved in glioma chemoresistance. ". J Neurochem. 2017. PMID 28581641.
"CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor. ". Nat Commun. 2017. PMID 28232751.
"An extensive program of periodic alternative splicing linked to cell cycle progression. ". Elife. 2016. PMID 27015110.
"Nuclear protein kinase CLK1 uses a non-traditional docking mechanism to select physiological substrates. ". Biochem J. 2015. PMID 26443864.
"Manipulation of alternative splicing by a newly developed inhibitor of Clks.". J Biol Chem. 2004. PMID 15010457.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CLK1 - Cronfa NCBI

[1]

[2]