CLTC

CLTC
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2XZG, 4G55
Dynodwyr
Cyfenwau	CLTC, CHC, CHC17, CLH-17, CLTCL2, Hc, clathrin heavy chain, MRD56
Dynodwyr allanol	OMIM: 118955 HomoloGene: 3572 GeneCards: CLTC
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001948, GO:0016582 protein binding; • double-stranded RNA binding; • protein kinase binding; • structural molecule activity; • RNA binding; • clathrin light chain binding; • disordered domain specific binding; • low-density lipoprotein particle receptor binding; • ubiquitin-specific protease binding;
Cydrannau o'r gell	• extracellular vesicle; • cytosol; • clathrin-coated endocytic vesicle membrane; • clathrin coat of coated pit; • trans-Golgi network membrane; • clathrin coat of trans-Golgi network vesicle; • focal adhesion; • melanosome; • Cellbilen; • endolysosome membrane; • clathrin-coated pit; • extracellular exosome; • cytoplasmic vesicle membrane; • GO:0016023 cytoplasmic vesicle; • clathrin-coated vesicle; • GO:0005578 extracellular matrix; • bilen; • mitotic spindle microtubule; • cytoplasm; • lysosome; • endosome; • spindle; • Cytosgerbwd; • clathrin coat; • clathrin complex; • GO:0009327 protein-containing complex; • intracellular membrane-bounded organelle; • clathrin-coated endocytic vesicle; • mitotic spindle; • intracellular anatomical structure;
Prosesau biolegol	• antigen processing and presentation of exogenous peptide antigen via MHC class II; • transferrin transport; • receptor internalization; • negative regulation of protein localization to plasma membrane; • retrograde transport, endosome to Golgi; • osteoblast differentiation; • vesicle-mediated transport; • negative regulation of hyaluronan biosynthetic process; • intracellular protein transport; • Wnt signaling pathway, planar cell polarity pathway; • regulation of mitotic spindle organization; • autophagy; • microtubule-based movement; • cell cycle; • Cellraniad; • membrane organization; • GO:0007067 Mitosis; • receptor-mediated endocytosis; • low-density lipoprotein particle receptor catabolic process; • low-density lipoprotein particle clearance; • clathrin coat assembly; • clathrin-dependent endocytosis; • amyloid-beta clearance by transcytosis;
	Sources:Amigo / QuickGO
Orthologau
	1213
	n/a
	ENSG00000141367
	n/a
	Q00610
	n/a
	NM_001288653; NM_004859
	n/a
	NP_001275582; NP_004850
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CLTC yw CLTC a elwir hefyd yn Clathrin heavy chain 1 a Clathrin heavy chain (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q23.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CLTC.

Hc
CHC
CHC17
CLH-17
CLTCL2

Llyfryddiaeth

"Clathrin regulates lymphocyte migration by driving actin accumulation at the cellular leading edge. ". Eur J Immunol. 2016. PMID 27405273.
"Clathrin mediates infectious hepatitis C virus particle egress. ". J Virol. 2015. PMID 25631092.
"CHC promotes tumor growth and angiogenesis through regulation of HIF-1α and VEGF signaling. ". Cancer Lett. 2013. PMID 23228632.
"Clathrin is required for postmitotic Golgi reassembly. ". FASEB J. 2012. PMID 21965600.
"A novel mechanism involved in the pathogenesis of Graves ophthalmopathy (GO): clathrin is a possible targeting molecule for inhibiting local immune response in the orbit.". J Clin Endocrinol Metab. 2011. PMID 21917865.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CLTC - Cronfa NCBI

[1]

[2]