CORO1A

CORO1A
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2AKF, 2AQ5, 2B4E
Dynodwyr
Cyfenwau	CORO1A, CLABP, CLIPINA, HCORO1, IMD8, TACO, p57, coronin 1A
Dynodwyr allanol	OMIM: 605000 HomoloGene: 6545 GeneCards: CORO1A
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001948, GO:0016582 protein binding; • protein C-terminus binding; • identical protein binding; • phosphatidylinositol 3-kinase binding; • protein homodimerization activity; • actin monomer binding; • myosin heavy chain binding; • cytoskeletal protein binding; • actin filament binding; • actin binding;
Cydrannau o'r gell	• phagocytic cup; • extracellular exosome; • cytoplasm; • actin cytoskeleton; • cell cortex; • cnewyllyn cell; • cell leading edge; • axon; • lamellipodium; • cortical actin cytoskeleton; • early endosome; • cell-cell junction; • bilen; • Microffilament; • phagocytic vesicle membrane; • Cellbilen; • GO:0016023 cytoplasmic vesicle; • immunological synapse; • Cytosgerbwd; • phagocytic vesicle; • cytosol;
Prosesau biolegol	• negative regulation of vesicle fusion; • calcium ion transport; • homeostasis of number of cells within a tissue; • negative regulation of actin nucleation; • ffagocytosis; • response to cytokine; • nerve growth factor signaling pathway; • T cell homeostasis; • positive regulation of cell migration; • regulation of actin cytoskeleton organization; • positive chemotaxis; • actin filament organization; • positive regulation of T cell proliferation; • cellular response to interleukin-4; • natural killer cell degranulation; • regulation of release of sequestered calcium ion into cytosol; • regulation of actin polymerization or depolymerization; • cell-substrate adhesion; • regulation of actin filament polymerization; • GO:1904089 negative regulation of neuron apoptotic process; • positive regulation of T cell activation; • regulation of cell shape; • innate immune response; • early endosome to recycling endosome transport; • cell migration; • actin cytoskeleton organization; • uropod organization; • immunological synapse formation; • leukocyte chemotaxis; • phagolysosome assembly;
	Sources:Amigo / QuickGO
Orthologau
	11151
	n/a
	ENSG00000102879
	n/a
	P31146
	n/a
	NM_001193333; NM_007074
	n/a
	NP_001180262; NP_009005
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CORO1A yw CORO1A a elwir hefyd yn Coronin a Coronin 1a (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16p11.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CORO1A.

p57
IMD8
TACO
CLABP
HCORO1
CLIPINA

Llyfryddiaeth

"Compound heterozygous CORO1A mutations in siblings with a mucocutaneous-immunodeficiency syndrome of epidermodysplasia verruciformis-HPV, molluscum contagiosum and granulomatous tuberculoid leprosy. ". J Clin Immunol. 2014. PMID 25073507.
"Identification of coronin-1a as a novel antibody target for clinically isolated syndrome and multiple sclerosis. ". J Neurochem. 2013. PMID 23745754.
"Emergent Role of Coronin-1a in Neuronal Signaling. ". Vitam Horm. 2017. PMID 28215292.
"Recurrent viral infections associated with a homozygous CORO1A mutation that disrupts oligomerization and cytoskeletal association. ". J Allergy Clin Immunol. 2016. PMID 26476480.
"Coronin 1 trimerization is essential to protect pathogenic mycobacteria within macrophages from lysosomal delivery.". FEBS Lett. 2014. PMID 25217836.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CORO1A - Cronfa NCBI

[1]

[2]