CREM

CREM
Dynodwyr
Cyfenwau	CREM, CREM-2, ICER, hCREM-2, cAMP responsive element modulator
Dynodwyr allanol	OMIM: 123812 HomoloGene: 84591 GeneCards: CREM
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • cAMP response element binding protein binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0001948, GO:0016582 protein binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cydrannau o'r gell	• cytoplasm; • transcription regulator complex; • cnewyllyn cell;
Prosesau biolegol	• cell differentiation; • GO:0009373 regulation of transcription, DNA-templated; • glycosphingolipid metabolic process; • proses rythmig; • transcription, DNA-templated; • fatty acid metabolic process; • multicellular organism development; • retinoic acid receptor signaling pathway; • regulation of circadian rhythm; • spermatogenesis; • glucose metabolic process; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • GO:0072468 signal transduction; • GO:1901227 negative regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologau
	1390
	n/a
	ENSG00000095794
	n/a
	Q03060
	n/a
NM_001267562; NM_001267563; NM_001267564; NM_001267565; NM_001267566;
	NM_001267567; NM_001267568; NM_001267569; NM_001267570; NM_001881; NM_181571; NM_182717; NM_182718; NM_182719; NM_182720; NM_182721; NM_182722; NM_182723; NM_182724; NM_182725; NM_182769; NM_182770; NM_182771; NM_182772; NM_182850; NM_182853; NM_183011; NM_183012; NM_183013; NM_183060; NM_001352445; NM_001352446; NM_001352465; NM_001352466; NM_001352467; NM_001394595; NM_001394598; NM_001394600; NM_001394602; NM_001394603; NM_001394605; NM_001394608; NM_001394610; NM_001394613; NM_001394614; NM_001394615; NM_001394616; NM_001394617; NM_001394618; NM_001394619; NM_001394620; NM_001394621; NM_001394622; NM_001394623; NM_001394625; NM_001394626; NM_001394627; NM_001394628; NM_001394629; NM_001394630; NM_001394631
	n/a
NP_001254491; NP_001254492; NP_001254493; NP_001254494; NP_001254495;
	NP_001254496; NP_001254497; NP_001254498; NP_001254499; NP_001872; NP_853549; NP_874386; NP_874387; NP_874388; NP_874389; NP_874390; NP_874392; NP_874393; NP_877570; NP_877571; NP_877572; NP_877573; NP_898829; NP_898830; NP_898831; NP_898883; NP_001339374; NP_001339375; NP_001339394; NP_001339395; NP_001339396
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CREM yw CREM a elwir hefyd yn cAMP-responsive element modulator (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10p11.21.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CREM.

ICER
CREM-2
hCREM-2

Llyfryddiaeth

"CREM variant rs17583959 conferred susceptibility to T1D risk in the Tunisian families. ". Immunol Lett. 2017. PMID 27840176.
"Constitutive Expression of Inducible Cyclic Adenosine Monophosphate Early Repressor (ICER) in Cycling Quiescent Hematopoietic Cells: Implications for Aging Hematopoietic Stem Cells. ". Stem Cell Rev. 2017. PMID 27822872.
"Cyclic AMP-Responsive Element Modulator α Polymorphisms Are Potential Genetic Risks for Systemic Lupus Erythematosus. ". J Immunol Res. 2015. PMID 26601115.
"CREM variants rs4934540 and rs2295415 conferred susceptibility to nonobstructive azoospermia risk in the Chinese population. ". Biol Reprod. 2014. PMID 24943041.
"Wide distribution of CREM immunoreactivity in adult and fetal human brain, with an increased expression in dentate gyrus neurons of Alzheimer's as compared to normal aging brains.". Amino Acids. 2013. PMID 24100545.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CREM - Cronfa NCBI

[1]

[2]