CSTF2

CSTF2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1P1T, 2J8P
Dynodwyr
Cyfenwau	CSTF2, CstF-64, cleavage stimulation factor subunit 2
Dynodwyr allanol	OMIM: 300907 HomoloGene: 80171 GeneCards: CSTF2
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nucleic acid binding; • GO:0001948, GO:0016582 protein binding; • mRNA binding; • RNA binding;
Cydrannau o'r gell	• mRNA cleavage and polyadenylation specificity factor complex; • cleavage body; • nucleoplasm; • cnewyllyn cell; • nuclear body;
Prosesau biolegol	• mRNA splicing, via spliceosome; • termination of RNA polymerase II transcription; • mRNA processing; • mRNA 3'-end processing; • pre-mRNA cleavage required for polyadenylation; • tRNA splicing, via endonucleolytic cleavage and ligation; • mRNA polyadenylation;
	Sources:Amigo / QuickGO
Orthologau
	1478
	n/a
	ENSG00000101811
	n/a
	P33240
	n/a
	NM_001306206; NM_001306209; NM_001325
	n/a
	NP_001293135; NP_001293138; NP_001316; NP_001293135.1
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CSTF2 yw CSTF2 a elwir hefyd yn BetaCstF-64 variant 2 a Cleavage stimulation factor subunit 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom X dynol, band Xq22.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CSTF2.

CstF-64

Llyfryddiaeth

"Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3'-UTR landscape across seven tumour types. ". Nat Commun. 2014. PMID 25409906.
"Transcriptome-wide analyses of CstF64-RNA interactions in global regulation of mRNA alternative polyadenylation. ". Proc Natl Acad Sci U S A. 2012. PMID 23112178.
"Characterization of a cleavage stimulation factor, 3' pre-RNA, subunit 2, 64 kDa (CSTF2) as a therapeutic target for lung cancer. ". Clin Cancer Res. 2011. PMID 21813631.
"Characterization of Rous sarcoma virus polyadenylation site use in vitro. ". Virology. 2008. PMID 18272196.
"Protein and RNA dynamics play key roles in determining the specific recognition of GU-rich polyadenylation regulatory elements by human Cstf-64 protein.". J Mol Biol. 2005. PMID 15769465.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CSTF2 - Cronfa NCBI

[1]

[2]