CTBP1

CTBP1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1MX3, 4LCE, 4U6Q
Dynodwyr
Cyfenwau	CTBP1, C-terminal binding protein 1, BARS, HADDTS
Dynodwyr allanol	OMIM: 602618 HomoloGene: 1015 GeneCards: CTBP1
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0050229 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; • GO:0001106 transcription corepressor activity; • protein domain specific binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • NAD binding; • transcription factor binding; • protein C-terminus binding; • GO:0001948, GO:0016582 protein binding; • oxidoreductase activity; • identical protein binding; • hydroxypyruvate reductase activity; • glyoxylate reductase (NADP+) activity; • protein homodimerization activity;
Cydrannau o'r gell	• cytoplasm; • transcription regulator complex; • transcription repressor complex; • nucleoplasm; • cnewyllyn cell; • cytosol; • presynaptic active zone cytoplasmic component; • glutamatergic synapse; • GABA-ergic synapse;
Prosesau biolegol	• positive regulation of histone deacetylation; • cell differentiation; • GO:0009373 regulation of transcription, DNA-templated; • viral genome replication; • GO:1901227 negative regulation of transcription by RNA polymerase II; • transcription, DNA-templated; • regulation of cell cycle; • negative regulation of histone H4 acetylation; • protein phosphorylation; • white fat cell differentiation; • metabolaeth; • GO:0022415 viral process; • GO:0045996 negative regulation of transcription, DNA-templated; • negative regulation of histone acetylation; • negative regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologau
	1487
	n/a
	ENSG00000159692
	n/a
	Q13363
	n/a
NM_001012614; NM_001328; NM_001377186; NM_001377187; NM_001377188;
	NM_001377189; NM_001377190; NM_001377191; NM_001377192; NM_001377193
	n/a
NP_001012632; NP_001319; NP_001364115; NP_001364116; NP_001364117;
	NP_001364118; NP_001364119; NP_001364120; NP_001364121; NP_001364122
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CTBP1 yw CTBP1 a elwir hefyd yn C-terminal-binding protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4p16.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CTBP1.

BARS

Llyfryddiaeth

"Silencing of CtBP1 suppresses the migration in human glioma cells. ". J Mol Histol. 2016. PMID 27160109.
"CtBP1 associates metabolic syndrome and breast carcinogenesis targeting multiple miRNAs. ". Oncotarget. 2016. PMID 26933806.
"Prostate tumor growth is impaired by CtBP1 depletion in high-fat diet-fed mice. ". Clin Cancer Res. 2014. PMID 24842953.
"Nicotinamide adenine dinucleotide-induced multimerization of the co-repressor CtBP1 relies on a switching tryptophan. ". J Biol Chem. 2013. PMID 23940047.
"CtBP1 is involved in epithelial-mesenchymal transition and is a potential therapeutic target for hepatocellular carcinoma.". Oncol Rep. 2013. PMID 23756565.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CTBP1 - Cronfa NCBI

[1]

[2]