CTSB

CTSB
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3PBH, 1CSB, 1GMY, 1HUC, 1PBH, 2IPP, 2PBH, 3AI8, 3CBJ, 3CBK, 3K9M
Dynodwyr
Cyfenwau	CTSB, APPS, CPSB, cathepsin B, RECEUP
Dynodwyr allanol	OMIM: 116810 HomoloGene: 37550 GeneCards: CTSB
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• cysteine-type peptidase activity; • collagen binding; • GO:0070122 peptidase activity; • GO:0001948, GO:0016582 protein binding; • cysteine-type endopeptidase activity; • hydrolase activity; • proteoglycan binding; • serine-type endopeptidase activity; • endopeptidase activity;
Cydrannau o'r gell	• intracellular membrane-bounded organelle; • melanosome; • intracellular anatomical structure; • extracellular region; • endolysosome lumen; • nucleolus; • mitocondria; • lysosome; • extracellular exosome; • perinuclear region of cytoplasm; • extracellular space; • ficolin-1-rich granule lumen; • collagen-containing extracellular matrix;
Prosesau biolegol	• regulation of apoptotic process; • epithelial cell differentiation; • proteolysis; • toll-like receptor signaling pathway; • decidualization; • cellular response to thyroid hormone stimulus; • collagen catabolic process; • viral entry into host cell; • GO:0048552 regulation of catalytic activity; • proteolysis involved in cellular protein catabolic process; • neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologau
	1508
	n/a
	ENSG00000164733; ENSG00000285132
	n/a
	P07858
	n/a
NM_001908; NM_147780; NM_147781; NM_147782; NM_147783;
	NM_001317237
	n/a
NP_001304166; NP_001899; NP_680090; NP_680091; NP_680092;
	NP_680093
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CTSB yw CTSB a elwir hefyd yn Cathepsin B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 8, band 8p23.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CTSB.

APPS
CPSB

Llyfryddiaeth

"Duplicated Enhancer Region Increases Expression of CTSB and Segregates with Keratolytic Winter Erythema in South African and Norwegian Families. ". Am J Hum Genet. 2017. PMID 28457472.
"Human macrophage cathepsin B-mediated C-terminal cleavage of apolipoprotein A-I at Ser228 severely impairs antiatherogenic capacity. ". FASEB J. 2016. PMID 27630170.
"Proteomic analysis of silenced cathepsin B expression suggests non-proteolytic cathepsin B functionality. ". Biochim Biophys Acta. 2016. PMID 27526672.
"Caffeine suppresses the progression of human glioblastoma via cathepsin B and MAPK signaling pathway. ". J Nutr Biochem. 2016. PMID 27260469.
"Cathepsin B Expression and the Correlation with Clinical Aspects of Oral Squamous Cell Carcinoma.". PLoS One. 2016. PMID 27031837.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CTSB - Cronfa NCBI

[1]

[2]