CTSK

CTSK
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1MEM, 3KWB, 3KX1, 4X6J, 1AYW, 3KW9, 1YT7, 1AU2, 4X6H, 1Q6K, 1YK7, 1ATK, 3C9E, 1AYV, 1BGO, 4N8W, 7PCK, 4DMX, 4X6I, 1NL6, 1TU6, 3O0U, 1AU4, 3OVZ, 3KWZ, 2ATO, 3O1G, 1AU0, 1BY8, 1SNK, 2AUZ, 4DMY, 4N79, 1AYU, 1U9X, 1YK8, 1AU3, 1U9V, 2BDL, 1VSN, 1U9W, 2AUX, 2R6N, 3H7D, 1NLJ, 5J94, 4YVA, 4YV8
Dynodwyr
Cyfenwau	CTSK, CTS02, CTSO, CTSO1, CTSO2, PKND, PYCD, cathepsin K
Dynodwyr allanol	OMIM: 601105 HomoloGene: 68053 GeneCards: CTSK
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• fibronectin binding; • cysteine-type peptidase activity; • collagen binding; • GO:0070122 peptidase activity; • GO:0001948, GO:0016582 protein binding; • cysteine-type endopeptidase activity; • hydrolase activity; • proteoglycan binding; • serine-type endopeptidase activity;
Cydrannau o'r gell	• cytoplasm; • extracellular region; • endolysosome lumen; • lysosome; • extracellular space; • nucleoplasm; • intracellular membrane-bounded organelle; • lysosomal lumen;
Prosesau biolegol	• intramembranous ossification; • positive regulation of protein targeting to mitochondrion; • extracellular matrix disassembly; • bone resorption; • proteolysis; • toll-like receptor signaling pathway; • regulation of autophagy of mitochondrion; • collagen catabolic process; • proteolysis involved in cellular protein catabolic process; • regulation of keratinocyte differentiation;
	Sources:Amigo / QuickGO
Orthologau
	1513
	n/a
	ENSG00000143387
	n/a
	P43235
	n/a
	NM_000396
	n/a
	NP_000387
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CTSK yw CTSK a elwir hefyd yn Cathepsin K (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q21.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CTSK.

CTSO
PKND
PYCD
CTS02
CTSO1
CTSO2

Llyfryddiaeth

"A composite docking approach for the identification and characterization of ectosteric inhibitors of cathepsin K. ". PLoS One. 2017. PMID 29088253.
"Cathepsin K in Lymphangioleiomyomatosis: LAM Cell-Fibroblast Interactions Enhance Protease Activity by Extracellular Acidification. ". Am J Pathol. 2017. PMID 28623674.
"Expression of Cathepsin K in Skull Base Chordoma. ". World Neurosurg. 2017. PMID 28216213.
"An allosteric site enables fine-tuning of cathepsin K by diverse effectors. ". FEBS Lett. 2016. PMID 27859061.
"Molecular analysis of the CTSK gene in a cohort of 33 Brazilian families with pycnodysostosis from a cluster in a Brazilian Northeast region.". Eur J Med Res. 2016. PMID 27558267.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CTSK - Cronfa NCBI

[1]

[2]