CTSL

CTSL
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1CJL, 1CS8, 1ICF, 1MHW, 2NQD, 2VHS, 2XU1, 2XU3, 2XU4, 2XU5, 2YJ2, 2YJ8, 2YJ9, 2YJB, 2YJC, 3BC3, 3H89, 3H8B, 3H8C, 3HHA, 3HWN, 3IV2, 3K24, 3KSE, 3OF8, 3OF9, 4AXL, 4AXM, 5F02, 5I4H
Dynodwyr
Cyfenwau	CTSL, CATL, CTSL1, MEP, cathepsin L
Dynodwyr allanol	OMIM: 116880 HomoloGene: 129366 GeneCards: CTSL
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• fibronectin binding; • cysteine-type peptidase activity; • collagen binding; • GO:0031493 histone binding; • serpin family protein binding; • GO:0070122 peptidase activity; • GO:0001948, GO:0016582 protein binding; • cysteine-type endopeptidase activity; • hydrolase activity; • proteoglycan binding; • serine-type endopeptidase activity;
Cydrannau o'r gell	• extracellular region; • endolysosome lumen; • lysosomal lumen; • lysosome; • extracellular exosome; • cnewyllyn cell; • extracellular space; • collagen-containing extracellular matrix; • multivesicular body; • Cellbilen;
Prosesau biolegol	• macrophage apoptotic process; • antigen processing and presentation; • adaptive immune response; • antigen processing and presentation of exogenous peptide antigen via MHC class II; • extracellular matrix disassembly; • proteolysis; • toll-like receptor signaling pathway; • cellular response to thyroid hormone stimulus; • collagen catabolic process; • proteolysis involved in cellular protein catabolic process; • regulation of keratinocyte differentiation;
	Sources:Amigo / QuickGO
Orthologau
	1514
	n/a
	ENSG00000135047
	n/a
	P07711; Q9HBQ7
	n/a
NM_001257971; NM_001257972; NM_001257973; NM_001912; NM_145918;
	NM_001382757; NM_001382758; NM_001382766; NM_001382767; NM_001382768
	n/a
NP_001244900; NP_001244901; NP_001244902; NP_001903; NP_666023;
	NP_001369686; NP_001369687; NP_001369695; NP_001369696; NP_001369697; NP_001244902.1
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CTSL yw CTSL a elwir hefyd yn Cathepsin L, isoform CRA_b a Cathepsin L (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 9, band 9q21.33.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CTSL.

MEP
CATL
CTSL1

Llyfryddiaeth

"Cathepsin L is involved in X-ray-induced invasion and migration of human glioma U251 cells. ". Cell Signal. 2017. PMID 27989700.
"The association between serum cathepsin L and mortality in older adults. ". Atherosclerosis. 2016. PMID 27718373.
"Cathepsin L knockdown enhances curcumin-mediated inhibition of growth, migration, and invasion of glioma cells. ". Brain Res. 2016. PMID 27373979.
"Cathepsin L in tumor angiogenesis and its therapeutic intervention by the small molecule inhibitor KGP94. ". Clin Exp Metastasis. 2016. PMID 27055649.
"Caught in the act: the crystal structure of cleaved cathepsin L bound to the active site of Cathepsin L.". FEBS Lett. 2016. PMID 26992470.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CTSL - Cronfa NCBI

[1]

[2]