CXCL5

CXCL5
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2MGS
Dynodwyr
Cyfenwau	CXCL5, ENA-78, SCYB5, C-X-C motif chemokine ligand 5
Dynodwyr allanol	OMIM: 600324 HomoloGene: 88672 GeneCards: CXCL5
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• CXCR chemokine receptor binding; • cytokine activity; • chemokine activity; • identical protein binding;
Cydrannau o'r gell	• extracellular region; • extracellular space;
Prosesau biolegol	• positive regulation of cell population proliferation; • inflammatory response; • response to lipopolysaccharide; • GO:0072468 signal transduction; • cell-cell signaling; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • chemokine-mediated signaling pathway; • cell chemotaxis; • neutrophil mediated immunity; • chemotaxis; • defense response; • positive regulation of neutrophil chemotaxis; • regulation of signaling receptor activity; • G protein-coupled receptor signaling pathway; • neutrophil chemotaxis; • leukocyte chemotaxis; • antimicrobial humoral immune response mediated by antimicrobial peptide; • cellular response to lipopolysaccharide;
	Sources:Amigo / QuickGO
Orthologau
	6374
	n/a
	ENSG00000163735
	n/a
	P42830
	n/a
	NM_002994
	n/a
	NP_002985
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CXCL5 yw CXCL5 a elwir hefyd yn C-X-C motif chemokine ligand 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4q13.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CXCL5.

SCYB5
ENA-78

Llyfryddiaeth

"Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3β/β-catenin pathways. ". Mol Cancer. 2017. PMID 28356111.
"CXCL5 Plays a Promoting Role in Osteosarcoma Cell Migration and Invasion in Autocrine- and Paracrine-Dependent Manners. ". Oncol Res. 2017. PMID 28277189.
"Neutrophil infiltration mediated by CXCL5 accumulation in the laryngeal squamous cell carcinoma microenvironment: A mechanism by which tumour cells escape immune surveillance. ". Clin Immunol. 2017. PMID 27876461.
"CXCL5 promotes the proliferation and migration of glioma cells in autocrine- and paracrine-dependent manners. ". Oncol Rep. 2016. PMID 27748886.
"Molecular Basis of Chemokine CXCL5-Glycosaminoglycan Interactions.". J Biol Chem. 2016. PMID 27471273.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CXCL5 - Cronfa NCBI

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[2]