CYLD

CYLD
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1IXD, 1WHL, 1WHM, 2VHF
Dynodwyr
Cyfenwau	CYLD, BRSS, CDMT, CYLD1, CYLDI, EAC, MFT, MFT1, SBS, TEM, USPL2, CYLD lysine 63 deubiquitinase
Dynodwyr allanol	OMIM: 605018 HomoloGene: 9069 GeneCards: CYLD
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• cysteine-type peptidase activity; • zinc ion binding; • metal ion binding; • GO:0070122 peptidase activity; • GO:0001948, GO:0016582 protein binding; • thiol-dependent deubiquitinase; • proline-rich region binding; • hydrolase activity; • protein kinase binding; • Lys63-specific deubiquitinase activity; • Lys48-specific deubiquitinase activity; • structural constituent of ribosome;
Cydrannau o'r gell	• cytoplasm; • cytosol; • centrosome; • cell projection; • bilen; • extrinsic component of cytoplasmic side of plasma membrane; • Cellbilen; • spindle; • microtubule organizing center; • midbody; • perinuclear region of cytoplasm; • cytoplasmic microtubule; • Cytosgerbwd; • microtubule; • ciliary basal body; • ciliary tip;
Prosesau biolegol	• regulation of intrinsic apoptotic signaling pathway; • ubiquitin-dependent protein catabolic process; • regulation of microtubule cytoskeleton organization; • Wnt signaling pathway; • proteolysis; • protein K63-linked deubiquitination; • regulation of mitotic cell cycle; • positive regulation of extrinsic apoptotic signaling pathway; • cell cycle; • negative regulation of type I interferon production; • negative regulation of NF-kappaB transcription factor activity; • nucleotide-binding oligomerization domain containing signaling pathway; • negative regulation of canonical Wnt signaling pathway; • immune system process; • regulation of tumor necrosis factor-mediated signaling pathway; • protein deubiquitination; • CD4-positive or CD8-positive, alpha-beta T cell lineage commitment; • regulation of protein binding; • innate immune response; • regulation of B cell differentiation; • negative regulation of T cell differentiation; • positive regulation of T cell differentiation; • homeostasis of number of cells; • positive regulation of T cell receptor signaling pathway; • GO:0060554, GO:0060555 necroptosis; • protein K48-linked deubiquitination; • ripoptosome assembly involved in necroptotic process; • regulation of cilium assembly; • positive regulation of protein localization; • protein linear deubiquitination; • cytoplasmic translation; • negative regulation of NIK/NF-kappaB signaling; • negative regulation of JNK cascade; • negative regulation of p38MAPK cascade; • regulation of inflammatory response; • regulation of necroptotic process;
	Sources:Amigo / QuickGO
Orthologau
	1540
	n/a
	ENSG00000083799
	n/a
	Q9NQC7
	n/a
	NM_001042355; NM_001042412; NM_015247
	n/a
NP_001035814; NP_001035877; NP_056062; NP_001365672; NP_001365673;
	NP_001365674; NP_001365675; NP_001365676; NP_001365677; NP_001365678; NP_001365679; NP_001365680; NP_001365681; NP_001365682; NP_001365683; NP_001365684; NP_001035814.1; NP_001035877.1
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CYLD yw CYLD a elwir hefyd yn Ubiquitin carboxyl-terminal hydrolase CYLD (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16q12.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CYLD.

EAC
MFT
SBS
TEM
BRSS
CDMT
MFT1
CYLD1
CYLDI
USPL2

Llyfryddiaeth

"Dishevelled proteins and CYLD reciprocally regulate each other in CML cell lines. ". Mol Biol Rep. 2017. PMID 28840581.
"The expression of tumor suppressor gene Cyld is upregulated by histone deacetylace inhibitors in human hepatocellular carcinoma cell lines. ". Cell Biochem Funct. 2016. PMID 27570065.
"The CYLD p.R758X worldwide recurrent nonsense mutation detected in patients with multiple familial trichoepithelioma type 1, Brooke-Spiegler syndrome and familial cylindromatosis represents a mutational hotspot in the gene. ". BMC Genet. 2016. PMID 26861065.
"UV Irradiation Triggers Cylindromatosis Translocation, Modification, and Degradation in a Proteasome-Independent Manner. ". DNA Cell Biol. 2016. PMID 26717101.
"Inherited cylindromas: lessons from a rare tumour.". Lancet Oncol. 2015. PMID 26370355.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CYLD - Cronfa NCBI

[1]

[2]