CYP11B2

CYP11B2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4DVQ, 4FDH, 4ZGX
Dynodwyr
Cyfenwau	CYP11B2, ALDOS, CPN2, CYP11B, CYP11BL, CYPXIB2, P-450C18, P450C18, P450aldo, cytochrome P450 family 11 subfamily B member 2
Dynodwyr allanol	OMIM: 124080 HomoloGene: 106948 GeneCards: CYP11B2
EC number	1.14.15.4
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• iron ion binding; • corticosterone 18-monooxygenase activity; • metal ion binding; • monooxygenase activity; • heme binding; • GO:0050602 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; • oxidoreductase activity; • steroid 11-beta-monooxygenase activity; • steroid hydroxylase activity;
Cydrannau o'r gell	• mitochondrial membranes; • bilen; • mitocondria; • mitochondrial inner membrane;
Prosesau biolegol	• lipid metabolism; • aldosterone biosynthetic process; • cortisol biosynthetic process; • C21-steroid hormone biosynthetic process; • cellular response to hormone stimulus; • potassium ion homeostasis; • mineralocorticoid biosynthetic process; • regulation of blood volume by renal aldosterone; • renal water homeostasis; • sterol metabolic process; • sodium ion homeostasis; • cellular response to potassium ion; • steroid biosynthetic process; • steroid metabolic process; • glucocorticoid biosynthetic process; • cholesterol metabolic process; • cellular response to peptide hormone stimulus; • cortisol metabolic process;
	Sources:Amigo / QuickGO
Orthologau
	1585
	n/a
	ENSG00000179142
	n/a
	P19099
	n/a
	NM_000498
	n/a
	NP_000489
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CYP11B2 yw CYP11B2 a elwir hefyd yn Cytochrome P450 family 11 subfamily B member 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 8, band 8q24.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CYP11B2.

CPN2
ALDOS
CYP11B
CYP11BL
CYPXIB2
P450C18
P-450C18
P450aldo

Llyfryddiaeth

"A novel haplotype of low-frequency variants in the aldosterone synthase gene among northern Han Chinese with essential hypertension. ". Medicine (Baltimore). 2017. PMID 28953657.
"Prognostic Value of Different Allelic Polymorphism of Aldosterone Synthase Receptor in a Congestive Heart Failure European Continental Ancestry Population. ". Arch Med Res. 2017. PMID 28625318.
"Age-Related Autonomous Aldosteronism. ". Circulation. 2017. PMID 28566337.
"The impact of the clinical CYP11B2 mutation V386A strongly depends on the enzyme's genetic background. ". Endocr J. 2017. PMID 28190867.
"Haplotype association and synergistic effect of human aldosterone synthase (CYP11B2) gene polymorphisms causing susceptibility to essential hypertension in Indian patients.". Clin Exp Hypertens. 2016. PMID 27935319.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CYP11B2 - Cronfa NCBI

[1]

[2]