CYP2A13

CYP2A13
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2P85, 2PG5, 2PG6, 2PG7, 3T3S, 4EJG, 4EJH, 4EJI
Dynodwyr
Cyfenwau	CYP2A13, CPAD, CYP2A, CYPIIA13, cytochrome P450 family 2 subfamily A member 13
Dynodwyr allanol	OMIM: 608055 HomoloGene: 85917 GeneCards: CYP2A13
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• iron ion binding; • oxidoreductase activity; • aromatase activity; • arachidonic acid epoxygenase activity; • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; • heme binding; • GO:0050602 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; • metal ion binding; • coumarin 7-hydroxylase activity; • steroid hydroxylase activity; • monooxygenase activity;
Cydrannau o'r gell	• organelle membrane; • endoplasmic reticulum membrane; • Reticwlwm endoplasmig; • bilen; • intracellular membrane-bounded organelle; • cytoplasm;
Prosesau biolegol	• xenobiotic metabolic process; • epoxygenase P450 pathway; • coumarin metabolic process; • organic acid metabolic process;
	Sources:Amigo / QuickGO
Orthologau
	1553
	n/a
	ENSG00000197838
	n/a
	Q16696
	n/a
	NM_000766
	n/a
	NP_000757
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CYP2A13 yw CYP2A13 a elwir hefyd yn Cytochrome P450 family 2 subfamily A member 13 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q13.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CYP2A13.

CPAD
CYP2A
CYPIIA13

Llyfryddiaeth

"CYP2A13 Genetic Polymorphisms in Relation to the Risk of Bladder Cancer in Japanese Smokers. ". Biol Pharm Bull. 2016. PMID 27725446.
"In vitro metabolism of N'-Nitrosonornicotine catalyzed by cytochrome P450 2A13 and its inhibition by nicotine, N'-Nitrosoanatabine and N'-Nitrosoanabasine. ". Chem Biol Interact. 2016. PMID 27567546.
"Suppression of pulmonary CYP2A13 expression by carcinogen-induced lung tumorigenesis in a CYP2A13-humanized mouse model. ". Drug Metab Dispos. 2015. PMID 25710941.
"Generation and characterization of a novel CYP2A13--transgenic mouse model. ". Drug Metab Dispos. 2014. PMID 24907355.
"Cytochrome P450 2A13 mediates the neoplastic transformation of human bronchial epithelial cells at a low concentration of aflatoxin B1.". Int J Cancer. 2014. PMID 24114584.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CYP2A13 - Cronfa NCBI

[1]

[2]