CYP2E1

CYP2E1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3E4E, 3E6I, 3GPH, 3KOH, 3LC4, 3T3Z
Dynodwyr
Cyfenwau	CYP2E1, CPE1, CYP2E, P450-J, P450C2E, cytochrome P450 family 2 subfamily E member 1
Dynodwyr allanol	OMIM: 124040 HomoloGene: 68089 GeneCards: CYP2E1
EC number	1.14.13.n7
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• iron ion binding; • oxygen binding; • arachidonic acid epoxygenase activity; • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; • metal ion binding; • monooxygenase activity; • heme binding; • GO:0050602 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; • enzyme binding; • oxidoreductase activity; • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; • steroid hydroxylase activity; • Hsp70 protein binding; • Hsp90 protein binding;
Cydrannau o'r gell	• organelle membrane; • endoplasmic reticulum membrane; • intracellular membrane-bounded organelle; • bilen; • intrinsic component of endoplasmic reticulum membrane; • Golgi membrane; • Reticwlwm endoplasmig; • mitocondria; • cytoplasm; • mitochondrial inner membrane;
Prosesau biolegol	• steroid metabolic process; • epoxygenase P450 pathway; • response to ozone; • heterocycle metabolic process; • response to organonitrogen compound; • monoterpenoid metabolic process; • xenobiotic metabolic process; • response to ethanol; • triglyceride metabolic process; • carbon tetrachloride metabolic process; • halogenated hydrocarbon metabolic process; • benzene metabolic process; • long-chain fatty acid biosynthetic process; • response to bacterium; • organic acid metabolic process;
	Sources:Amigo / QuickGO
Orthologau
	1571
	n/a
	ENSG00000130649
	n/a
	P05181
	n/a
	NM_000773
	n/a
	NP_000764
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CYP2E1 yw CYP2E1 a elwir hefyd yn Cytochrome P450 2E1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10q26.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CYP2E1.

CPE1
CYP2E
P450-J
P450C2E

Llyfryddiaeth

"CYP2E1 Gene Polymorphisms Related to the Formation of Coronary Artery Lesions in Kawasaki Disease. ". Pediatr Infect Dis J. 2017. PMID 28650933.
"Cytochrome P450 2E1 increases the sensitivity of hepatoma cells to vitamin K2. ". Int J Oncol. 2017. PMID 28339022.
"Does CYP2E1 RsaI/PstI polymorphism confer head and neck carcinoma susceptibility?: A meta-analysis based on 43 studies. ". Medicine (Baltimore). 2016. PMID 27787372.
"Meta-analysis of CYP2E1 polymorphisms in liver carcinogenesis. ". Dig Liver Dis. 2017. PMID 27637154.
"CYP2E1 polymorphisms and nasopharyngeal carcinoma risk: a meta-analysis.". Eur Arch Otorhinolaryngol. 2017. PMID 27491320.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CYP2E1 - Cronfa NCBI

[1]

[2]