CYP46A1

CYP46A1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4FIA, 2Q9F, 3MDV, 4J14, 4ENH, 2Q9G, 3MDM, 3MDT, 3MDR
Dynodwyr
Cyfenwau	CYP46A1, CP46, CYP46, cytochrome P450 family 46 subfamily A member 1
Dynodwyr allanol	OMIM: 604087 HomoloGene: 134501 GeneCards: CYP46A1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• iron ion binding; • metal ion binding; • monooxygenase activity; • steroid hydroxylase activity; • heme binding; • GO:0050602 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; • oxidoreductase activity; • cholesterol 24-hydroxylase activity;
Cydrannau o'r gell	• organelle membrane; • integral component of membrane; • endoplasmic reticulum membrane; • bilen; • intracellular membrane-bounded organelle; • Reticwlwm endoplasmig; • dendrite; • presynapse; • postsynapse; • cell junction; • cell projection; • synapse;
Prosesau biolegol	• steroid metabolic process; • lipid metabolism; • cholesterol metabolic process; • cholesterol catabolic process; • nervous system development; • sterol metabolic process; • bile acid biosynthetic process; • xenobiotic metabolic process; • progesterone metabolic process; • regulation of long-term synaptic potentiation; • C21-steroid hormone metabolic process;
	Sources:Amigo / QuickGO
Orthologau
	10858
	n/a
	ENSG00000036530
	n/a
	Q9Y6A2
	n/a
	NM_006668
	n/a
	NP_006659
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CYP46A1 yw CYP46A1 a elwir hefyd yn Cytochrome P450 family 46 subfamily A member 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q32.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CYP46A1.

CP46
CYP46

Llyfryddiaeth

"Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1. ". J Lipid Res. 2014. PMID 25017465.
"CYP46A1 intron-2T/C polymorphism and Alzheimer's disease: an updated meta-analysis of 16 studies including 3,960 cases and 3,828 controls. ". Neurosci Lett. 2013. PMID 23792195.
"In vitrocytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds. ". J Biol Chem. 2017. PMID 28642370.
"The association between CYP46A1 rs4900442 polymorphism and the risk of Alzheimer's disease: A meta-analysis. ". Neurosci Lett. 2016. PMID 27026489.
"Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology.". Hum Mol Genet. 2015. PMID 26358780.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CYP46A1 - Cronfa NCBI

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[2]