DAG1

DAG1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1EG4, 2MK7
Dynodwyr
Cyfenwau	DAG1, 156DAG, A3a, AGRNR, DAG, MDDGC7, MDDGC9, MDDGA9, dystroglycan 1, LGMDR16
Dynodwyr allanol	OMIM: 128239 HomoloGene: 3234 GeneCards: DAG1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• calcium ion binding; • GO:0001948, GO:0016582 protein binding; • virus receptor activity; • alpha-actinin binding; • vinculin binding; • actin binding; • tubulin binding; • structural constituent of muscle; • SH2 domain binding; • laminin binding; • laminin-1 binding; • dystroglycan binding;
Cydrannau o'r gell	• cell-cell junction; • cnewyllyn cell; • synapse; • contractile ring; • filopodium; • node of Ranvier; • costamere; • lamellipodium; • dystroglycan complex; • membrane raft; • cell junction; • Cytosgerbwd; • bilen; • extracellular exosome; • basolateral plasma membrane; • postsynaptic membrane; • sarcolemma; • cytoplasm; • integral component of membrane; • focal adhesion; • Cellbilen; • dystrophin-associated glycoprotein complex; • nucleoplasm; • basement membrane; • cytosol; • extracellular space; • endoplasmic reticulum lumen; • Golgi lumen; • plasma membrane raft; • external side of plasma membrane; • nuclear periphery; • GO:0005578 extracellular matrix; • extracellular region; • collagen-containing extracellular matrix; • glutamatergic synapse; • GABA-ergic synapse; • postsynaptic cytosol;
Prosesau biolegol	• NLS-bearing protein import into nucleus; • extracellular matrix organization; • GO:0022415 viral process; • regulation of embryonic cell shape; • response to peptide hormone; • regulation of epithelial to mesenchymal transition; • positive regulation of basement membrane assembly involved in embryonic body morphogenesis; • viral entry into host cell; • regulation of gastrulation; • negative regulation of cell migration; • Schwann cell development; • membrane protein ectodomain proteolysis; • calcium-dependent cell-matrix adhesion; • negative regulation of MAPK cascade; • nerve maturation; • microtubule anchoring; • commissural neuron axon guidance; • branching involved in salivary gland morphogenesis; • negative regulation of protein kinase B signaling; • morphogenesis of an epithelial sheet; • myelination in peripheral nervous system; • basement membrane organization; • epithelial tube branching involved in lung morphogenesis; • modulation by virus of host process; • protein O-linked glycosylation; • positive regulation of cell-matrix adhesion; • GO:0010260 heneiddio; • Schwann cell differentiation; • response to denervation involved in regulation of muscle adaptation; • nerve development; • axon regeneration; • positive regulation of myelination; • skeletal muscle tissue regeneration; • positive regulation of protein kinase activity; • positive regulation of oligodendrocyte differentiation; • cellular response to mechanical stimulus; • cellular response to cholesterol; • angiogenesis involved in wound healing; • GO:1904739 regulation of synapse organization; • regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; • retrograde trans-synaptic signaling by trans-synaptic protein complex;
	Sources:Amigo / QuickGO
Orthologau
	1605
	n/a
	ENSG00000173402
	n/a
	Q14118
	n/a
NM_004393; NM_001165928; NM_001177634; NM_001177635; NM_001177636;
	NM_001177637; NM_001177638; NM_001177639; NM_001177640; NM_001177641; NM_001177642; NM_001177643; NM_001177644
	n/a
NP_001159400; NP_001171105; NP_001171106; NP_001171107; NP_001171108;
	NP_001171109; NP_001171110; NP_001171111; NP_001171112; NP_001171113; NP_001171114; NP_001171115; NP_004384
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DAG1 yw DAG1 a elwir hefyd yn Dystroglycan a Dystroglycan 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3p21.31.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DAG1.

A3a
DAG
AGRNR
156DAG
MDDGA9
MDDGC7
MDDGC9

Llyfryddiaeth

"A role for dystroglycan in the pathophysiology of acute leukemic cells. ". Life Sci. 2017. PMID 28591567.
"DAG1 mutations associated with asymptomatic hyperCKemia and hypoglycosylation of α-dystroglycan. ". Neurology. 2015. PMID 25503980.
"Reduction of α-dystroglycan expression is correlated with poor prognosis in glioma. ". Tumour Biol. 2014. PMID 25139094.
"Dystroglycan depletion inhibits the functions of differentiated HL-60 cells. ". Biochem Biophys Res Commun. 2014. PMID 24792180.
"Hypoglycosylation of dystroglycan due to T192M mutation: a molecular insight behind the fact.". Gene. 2014. PMID 24361964.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] DAG1 - Cronfa NCBI

[1]

[2]