DCK

DCK
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1P5Z, 1P60, 1P61, 1P62, 2A2Z, 2A30, 2A7Q, 2NO0, 2NO1, 2NO6, 2NO7, 2NO9, 2NOA, 2QRN, 2QRO, 2ZI3, 2ZI4, 2ZI5, 2ZI6, 2ZI7, 2ZI9, 2ZIA, 3HP1, 3IPX, 3IPY, 3KFX, 3MJR, 3QEJ, 3QEN, 3QEO, 4JLJ, 4JLK, 4JLM, 4JLN, 4KCG, 4L5B, 4Q18, 4Q19, 4Q1A, 4Q1B, 4Q1C, 4Q1D, 4Q1E, 4Q1F
Dynodwyr
Cyfenwau	DCK, entrez:1633, deoxycytidine kinase
Dynodwyr allanol	OMIM: 125450 HomoloGene: 616 GeneCards: DCK
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • nucleoside kinase activity • deoxycytidine kinase activity • ATP binding • protein homodimerization activity • kinase activity • deoxynucleoside kinase activity Cydrannau o'r gell • cytosol • cnewyllyn cell • cytoplasm Prosesau biolegol • pyrimidine nucleoside salvage • pyrimidine nucleotide metabolic process • purine-containing compound salvage • nucleobase-containing compound metabolic process • phosphorylation • deoxyribonucleoside monophosphate biosynthetic process • nucleotide biosynthetic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1633	n/a
Ensembl	ENSG00000156136	n/a
UniProt	P27707	n/a
RefSeq (mRNA)	NM_000788	n/a
RefSeq (protein)	NP_000779	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DCK yw DCK a elwir hefyd yn Deoxycytidine kinase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 4, band 4q13.3.^[2]

Llyfryddiaeth

• "dCK Expression and Gene Polymorphism With Gemcitabine Chemosensitivity in Patients With Pancreatic Ductal Adenocarcinoma: A Strobe-Compliant Observational Study. ". Medicine (Baltimore). 2016. PMID 26962792.
• "Potent Sensitisation of Cancer Cells to Anticancer Drugs by a Quadruple Mutant of the Human Deoxycytidine Kinase. ". PLoS One. 2015. PMID 26485161.
• "Acquisition of chemoresistance to gemcitabine is induced by a loss-of-function missense mutation of DCK. ". Biochem Biophys Res Commun. 2015. PMID 26196746.
• "Impact of single nucleotide polymorphisms of cytarabine metabolic genes on drug toxicity in childhood acute lymphoblastic leukemia. ". Pediatr Blood Cancer. 2015. PMID 25557962.
• "Hypoxia-induced deoxycytidine kinase contributes to epithelial proliferation in pulmonary fibrosis.". Am J Respir Crit Care Med. 2014. PMID 25358054.

Cyfeiriadau

1. "Human PubMed Reference:".
2. DCK - Cronfa NCBI