DCN

DCN
Dynodwyr
Cyfenwau	DCN, Dcn, DC, DSPG2, PG40, PGII, PGS2, SLRR1B, mDcn, CSCD, decorin
Dynodwyr allanol	OMIM: 125255 HomoloGene: 22430 GeneCards: DCN
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• collagen binding; • protein N-terminus binding; • protein kinase inhibitor activity; • glycosaminoglycan binding; • extracellular matrix binding; • GO:0001948, GO:0016582 protein binding; • RNA binding; • extracellular matrix structural constituent conferring compression resistance;
Cydrannau o'r gell	• cytoplasm; • GO:0005578 extracellular matrix; • lysosomal lumen; • Golgi lumen; • collagen type VI trimer; • extracellular space; • extracellular region; • collagen-containing extracellular matrix;
Prosesau biolegol	• glycosaminoglycan metabolic process; • positive regulation of mitochondrial fission; • negative regulation of protein kinase activity; • positive regulation of autophagy; • kidney development; • cytokine-mediated signaling pathway; • placenta development; • chondroitin sulfate biosynthetic process; • response to mechanical stimulus; • GO:0010260 heneiddio; • extracellular matrix disassembly; • extracellular matrix organization; • wound healing; • negative regulation of endothelial cell migration; • positive regulation of macroautophagy; • response to lipopolysaccharide; • positive regulation of mitochondrial depolarization; • animal organ morphogenesis; • chondroitin sulfate catabolic process; • negative regulation of angiogenesis; • positive regulation of phosphatidylinositol 3-kinase signaling; • peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan; • negative regulation of vascular endothelial growth factor signaling pathway; • dermatan sulfate biosynthetic process; • skeletal muscle tissue development; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • negative regulation of receptor signaling pathway via JAK-STAT;
	Sources:Amigo / QuickGO
Orthologau
	1634
	n/a
	ENSG00000011465
	n/a
	P07585
	n/a
NM_001920; NM_133503; NM_133504; NM_133505; NM_133506;
	NM_133507
	n/a
NP_001911; NP_598010; NP_598011; NP_598012; NP_598013;
	NP_598014
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DCN yw DCN a elwir hefyd yn Decorin (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12q21.33.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DCN.

CSCD
PG40
PGII
PGS2
DSPG2
SLRR1B

Llyfryddiaeth

"Role of Decorin Core Protein in Collagen Organisation in Congenital Stromal Corneal Dystrophy (CSCD). ". PLoS One. 2016. PMID 26828927.
"Decorin: A Growth Factor Antagonist for Tumor Growth Inhibition. ". Biomed Res Int. 2015. PMID 26697491.
"Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology. ". FEBS J. 2017. PMID 27860287.
"Decorin Genotypes, Serum Glucose, Heart Rate, and Cerebrovascular Events: The Tampere Adult Population Cardiovascular Risk Study. ". Genet Test Mol Biomarkers. 2016. PMID 27315044.
"Posterior amorphous corneal dystrophy caused by a de novo deletion.". Ophthalmic Genet. 2017. PMID 27096414.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] DCN - Cronfa NCBI

[1]

[2]