DDB2

DDB2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3EI4, 3I7L, 4E54, 4E5Z
Dynodwyr
Cyfenwau	DDB2, DDBB, UV-XPE, damage specific DNA binding protein 2
Dynodwyr allanol	OMIM: 600811 HomoloGene: 83 GeneCards: DDB2
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • GO:0050372 ubiquitin-protein transferase activity; • GO:0001948, GO:0016582 protein binding; • damaged DNA binding; • GO:0032403 protein-containing complex binding;
Cydrannau o'r gell	• nucleoplasm; • cell junction; • Cul4B-RING E3 ubiquitin ligase complex; • cnewyllyn cell; • Cul4-RING E3 ubiquitin ligase complex; • GO:0009327 protein-containing complex;
Prosesau biolegol	• nucleotide-excision repair; • pyrimidine dimer repair; • nucleotide-excision repair, DNA damage recognition; • histone H2A monoubiquitination; • protein polyubiquitination; • cellular response to DNA damage stimulus; • global genome nucleotide-excision repair; • protein ubiquitination; • nucleotide-excision repair, DNA incision; • UV-damage excision repair; • response to UV; • GO:0100026 DNA repair; • protein autoubiquitination; • nucleotide-excision repair, DNA incision, 5'-to lesion; • nucleotide-excision repair, preincision complex stabilization; • nucleotide-excision repair, preincision complex assembly; • protein deubiquitination; • post-translational protein modification; • response to UV-B; • nucleotide-excision repair, DNA duplex unwinding; • nucleotide-excision repair, DNA incision, 3'-to lesion;
	Sources:Amigo / QuickGO
Orthologau
	1643
	n/a
	ENSG00000134574
	n/a
	Q92466
	n/a
	NM_000107; NM_001300734
	n/a
	NP_000098; NP_001287663
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DDB2 yw DDB2 a elwir hefyd yn Damage specific DNA binding protein 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11p11.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DDB2.

XPE
DDBB
UV-DDB2

Llyfryddiaeth

"UV radiation-induced SUMOylation of DDB2 regulates nucleotide excision repair. ". Carcinogenesis. 2017. PMID 28981631.
"DDB2 (damaged-DNA binding 2) protein: a new modulator of nanomechanical properties and cell adhesion of breast cancer cells. ". Nanoscale. 2016. PMID 26879405.
"The 5'-UTR of DDB2 harbors an IRES element and upregulates translation during stress conditions. ". Gene. 2015. PMID 26187069.
"DDB2 suppresses tumorigenicity by limiting the cancer stem cell population in ovarian cancer. ". Mol Cancer Res. 2014. PMID 24574518.
"A novel DDB2-ATM feedback loop regulates human cytomegalovirus replication.". J Virol. 2014. PMID 24335308.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] DDB2 - Cronfa NCBI

[1]

[2]