DEFA5

DEFA5
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1ZMP, 2LXZ, 2MIT, 3I5W, 4E82, 4E83, 4E86, 4RBW, 4RBX, 5CUM, 5CUJ, 5CUI
Dynodwyr
Cyfenwau	DEFA5, DEF5, HD-5, defensin alpha 5, alpha defensin 5
Dynodwyr allanol	OMIM: 600472 HomoloGene: 128604 GeneCards: DEFA5
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein homodimerization activity;
Cydrannau o'r gell	• Golgi lumen; • secretory granule lumen; • transport vesicle; • GO:0016023 cytoplasmic vesicle; • extracellular region; • extracellular space;
Prosesau biolegol	• defense response; • defense response to bacterium; • defense response to fungus; • antimicrobial humoral response; • antimicrobial humoral immune response mediated by antimicrobial peptide; • innate immune response; • positive regulation of membrane permeability; • killing of cells of other organism; • innate immune response in mucosa; • antibacterial humoral response; • GO:0051636 defense response to Gram-negative bacterium; • GO:0051637 defense response to Gram-positive bacterium; • membrane disruption in other organism; • cellular response to lipopolysaccharide;
	Sources:Amigo / QuickGO
Orthologau
	1670
	n/a
	ENSG00000164816; ENSG00000285251
	n/a
	Q01523
	n/a
	NM_021010
	n/a
	NP_066290
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DEFA5 yw DEFA5 a elwir hefyd yn Defensin alpha 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 8, band 8p23.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DEFA5.

DEF5
HD-5

Llyfryddiaeth

"Human alpha defensin 5 is a candidate biomarker to delineate inflammatory bowel disease. ". PLoS One. 2017. PMID 28817680.
"α-Defensin HD5 Inhibits Human Papillomavirus 16 Infection via Capsid Stabilization and Redirection to the Lysosome. ". MBio. 2017. PMID 28119475.
"Studies on the Interaction of Tumor-Derived HD5 Alpha Defensins with Adenoviruses and Implications for Oncolytic Adenovirus Therapy. ". J Virol. 2017. PMID 28077642.
"Antimicrobial activity of human α-defensin 5 and its linear analogs: N-terminal fatty acylation results in enhanced antimicrobial activity of the linear analogs. ". Peptides. 2015. PMID 26206286.
"Conformational landscape and pathway of disulfide bond reduction of human alpha defensin.". Protein Sci. 2015. PMID 25970658.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] DEFA5 - Cronfa NCBI

[1]

[2]