DFFA

DFFA
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1IBX, 1IYR, 1KOY
Dynodwyr
Cyfenwau	DFFA, DFF-45, DFF1, ICAD, DNA fragmentation factor subunit alpha
Dynodwyr allanol	OMIM: 601882 HomoloGene: 3240 GeneCards: DFFA
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001948, GO:0016582 protein binding; • protein domain specific binding; • protein folding chaperone activity; • deoxyribonuclease inhibitor activity;
Cydrannau o'r gell	• cytosol; • lipid droplet; • intracellular anatomical structure; • cnewyllyn cell; • nucleoplasm; • cytoplasm; • Cellbilen;
Prosesau biolegol	• positive regulation of apoptotic process; • negative regulation of execution phase of apoptosis; • negative regulation of apoptotic DNA fragmentation; • apoptotic DNA fragmentation; • thymocyte apoptotic process; • GO:0097285 apoptotic process; • negative regulation of deoxyribonuclease activity; • chaperone-mediated protein folding;
	Sources:Amigo / QuickGO
Orthologau
	1676
	n/a
	ENSG00000160049
	n/a
	O00273
	n/a
	NM_213566; NM_004401
	n/a
	NP_004392; NP_998731; NP_998731.1
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DFFA yw DFFA a elwir hefyd yn DNAation factor, 45kDa, alpha polypeptide, isoform CRA_b a DNA fragmentation factor subunit alpha (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p36.22.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DFFA.

DFF1
ICAD
DFF-45

Llyfryddiaeth

"siRNA-mediated knock-down of DFF45 amplifies doxorubicin therapeutic effects in breast cancer cells. ". Cell Oncol (Dordr). 2013. PMID 24277473.
"DFF45 expression in human endometrium is associated with menstrual cycle phases and decreases after menopause. ". Gynecol Obstet Invest. 2012. PMID 22378161.
"DFF45 expression in ovarian endometriomas. ". Eur J Obstet Gynecol Reprod Biol. 2009. PMID 19535198.
"Identification and characterization of the human inhibitor of caspase-activated DNase gene promoter. ". Apoptosis. 2008. PMID 18500556.
"Antiapoptotic regulation by hepatitis C virus core protein through up-regulation of inhibitor of caspase-activated DNase.". Virology. 2003. PMID 14675622.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] DFFA - Cronfa NCBI

[1]

[2]