DHX58

DHX58
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2RQA, 2W4R, 3EQT
Dynodwyr
Cyfenwau	DHX58, D11LGP2, D11lgp2e, LGP2, RLR-3, DEXH-box helicase 58
Dynodwyr allanol	OMIM: 608588 HomoloGene: 69371 GeneCards: DHX58
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • nucleotide binding; • GO:0008026 helicase activity; • zinc ion binding; • metal ion binding; • GO:0001948, GO:0016582 protein binding; • single-stranded RNA binding; • RNA binding; • double-stranded RNA binding; • hydrolase activity; • ATP binding;
Cydrannau o'r gell	• cytoplasm;
Prosesau biolegol	• negative regulation of MDA-5 signaling pathway; • regulation of innate immune response; • immune system process; • response to virus; • positive regulation of RIG-I signaling pathway; • defense response to virus; • negative regulation of innate immune response; • negative regulation of type I interferon production; • innate immune response; • GO:0022415 viral process; • positive regulation of MDA-5 signaling pathway; • positive regulation of type I interferon production; • negative regulation of RIG-I signaling pathway; • response to bacterium;
	Sources:Amigo / QuickGO
Orthologau
	79132
	n/a
	ENSG00000108771
	n/a
	Q96C10
	n/a
	NM_024119
	n/a
	NP_077024
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DHX58 yw DHX58 a elwir hefyd yn Probable ATP-dependent RNA helicase DHX58 a DExH-box helicase 58 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q21.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DHX58.

LGP2
RLR-3
D11LGP2
D11lgp2e

Llyfryddiaeth

"The innate immune sensor LGP2 activates antiviral signaling by regulating MDA5-RNA interaction and filament assembly. ". Mol Cell. 2014. PMID 25127512.
"LGP2 downregulates interferon production during infection with seasonal human influenza A viruses that activate interferon regulatory factor 3. ". J Virol. 2012. PMID 22837208.
"ATP hydrolysis enhances RNA recognition and antiviral signal transduction by the innate immune sensor, laboratory of genetics and physiology 2 (LGP2). ". J Biol Chem. 2013. PMID 23184951.
"Laboratory of genetics and physiology 2 (LGP2) plays an essential role in hepatitis C virus infection-induced interferon responses. ". Hepatology. 2017. PMID 28090671.
"LGP2 synergy with MDA5 in RLR-mediated RNA recognition and antiviral signaling.". Cytokine. 2015. PMID 25794939.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] DHX58 - Cronfa NCBI

[1]

[2]