DNMT3B

DNMT3B
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3QKJ, 3FLG, 5CIU
Dynodwyr
Cyfenwau	DNMT3B, ICF, ICF1, M.HsaIIIB, DNA (cytosine-5-)-methyltransferase 3 beta, DNA methyltransferase 3 beta, FSHD4
Dynodwyr allanol	OMIM: 602900 HomoloGene: 56000 GeneCards: DNMT3B
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0102674, GO:0102675 methyltransferase activity; • transferase activity; • DNA binding; • GO:0001106 transcription corepressor activity; • DNA-methyltransferase activity; • chromatin binding; • metal ion binding; • GO:0001948, GO:0016582 protein binding; • DNA (cytosine-5-)-methyltransferase activity; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • histone deacetylase binding;
Cydrannau o'r gell	• cytoplasm; • intracellular membrane-bounded organelle; • nucleoplasm; • cnewyllyn cell;
Prosesau biolegol	• response to ionizing radiation; • C-5 methylation of cytosine; • response to estradiol; • response to hypoxia; • cellular response to hyperoxia; • GO:1901227 negative regulation of transcription by RNA polymerase II; • response to activity; • cellular response to dexamethasone stimulus; • response to vitamin A; • DNA methylation; • methylation; • GO:1901313 positive regulation of gene expression; • negative regulation of gene expression, epigenetic; • positive regulation of histone H3-K4 methylation; • positive regulation of neuron differentiation; • negative regulation of histone H3-K9 methylation; • regulation of gene expression; • response to caffeine; • response to toxic substance; • adwaith i gocên;
	Sources:Amigo / QuickGO
Orthologau
	1789
	n/a
	ENSG00000088305
	n/a
	Q9UBC3
	n/a
NM_001207055; NM_001207056; NM_006892; NM_175848; NM_175849;
	NM_175850
	n/a
NP_001193984; NP_001193985; NP_008823; NP_787044; NP_787045;
	NP_787046
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DNMT3B yw DNMT3B a elwir hefyd yn DNA methyltransferase 3 beta (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 20, band 20q11.21.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DNMT3B.

ICF
ICF1
M.HsaIIIB

Llyfryddiaeth

"ICF-specific DNMT3B dysfunction interferes with intragenic regulation of mRNA transcription and alternative splicing. ". Nucleic Acids Res. 2017. PMID 28334849.
"Kaempferol Modulates DNA Methylation and Downregulates DNMT3B in Bladder Cancer. ". Cell Physiol Biochem. 2017. PMID 28278502.
"Association between DNA methyltransferase gene polymorphism and Parkinson's disease. ". Neurosci Lett. 2017. PMID 28041964.
"Associations of DNMT3B -149C>T and -2437T>A polymorphisms and lung cancer risk in Chinese population. ". World J Surg Oncol. 2016. PMID 27876061.
"A Novel Mutation in a Critical Region for the Methyl Donor Binding in DNMT3B Causes Immunodeficiency, Centromeric Instability, and Facial Anomalies Syndrome (ICF).". J Clin Immunol. 2016. PMID 27734333.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] DNMT3B - Cronfa NCBI

[1]

[2]