DRAP1

DRAP1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1JFI
Dynodwyr
Cyfenwau	DRAP1, NC2-alpha, DR1 associated protein 1
Dynodwyr allanol	OMIM: 602289 HomoloGene: 4703 GeneCards: DRAP1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein heterodimerization activity; • GO:0001948, GO:0016582 protein binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0001106 transcription corepressor activity; • DNA binding; • identical protein binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • chromatin binding; • GO:0001105 transcription coactivator activity; • transcription factor binding; • GO:0001104 transcription coregulator activity;
Cydrannau o'r gell	• cnewyllyn cell;
Prosesau biolegol	• transcription, DNA-templated; • GO:1901227 negative regulation of transcription by RNA polymerase II; • GO:0009373 regulation of transcription, DNA-templated; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • RNA polymerase II preinitiation complex assembly;
	Sources:Amigo / QuickGO
Orthologau
	10589
	n/a
	ENSG00000175550
	n/a
	Q14919
	n/a
	NM_006442
	n/a
	NP_006433
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DRAP1 yw DRAP1 a elwir hefyd yn DR1 associated protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q13.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DRAP1.

NC2-alpha

Llyfryddiaeth

"The C-terminal domain-phosphorylated IIO form of RNA polymerase II is associated with the transcription repressor NC2 (Dr1/DRAP1) and is required for transcription activation in human nuclear extracts. ". Proc Natl Acad Sci U S A. 2000. PMID 10852970.
"Regulation of nuclear import and export of negative cofactor 2. ". J Biol Chem. 2009. PMID 19204005.
"NC2 mobilizes TBP on core promoter TATA boxes. ". Nat Struct Mol Biol. 2007. PMID 17994103.
"Global distribution of negative cofactor 2 subunit-alpha on human promoters. ". Proc Natl Acad Sci U S A. 2007. PMID 17548813.
"Hypoxia actively represses transcription by inducing negative cofactor 2 (Dr1/DrAP1) and blocking preinitiation complex assembly.". J Biol Chem. 2003. PMID 12477712.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] DRAP1 - Cronfa NCBI

[1]

[2]