DVL3

DVL3
Dynodwyr
Cyfenwau	DVL3, DRS3, dishevelled segment polarity protein 3
Dynodwyr allanol	OMIM: 601368 HomoloGene: 20928 GeneCards: DVL3
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• beta-catenin binding; • GO:0005110 frizzled binding; • protease binding; • GO:0001948, GO:0016582 protein binding; • protein heterodimerization activity; • signaling receptor binding;
Cydrannau o'r gell	• cytoplasm; • cytosol;
Prosesau biolegol	• positive regulation of protein phosphorylation; • GO:0007243 intracellular signal transduction; • positive regulation of JUN kinase activity; • protein stabilization; • Wnt signaling pathway; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • multicellular organism development; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • negative regulation of canonical Wnt signaling pathway; • beta-catenin destruction complex disassembly; • non-canonical Wnt signaling pathway; • non-canonical Wnt signaling pathway via JNK cascade; • canonical Wnt signaling pathway; • Wnt signaling pathway, planar cell polarity pathway; • planar cell polarity pathway involved in neural tube closure; • positive regulation of neuron projection arborization;
	Sources:Amigo / QuickGO
Orthologau
	1857
	n/a
	ENSG00000161202
	n/a
	Q92997
	n/a
	NM_004423
	n/a
	NP_004414
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DVL3 yw DVL3 a elwir hefyd yn Dishevelled segment polarity protein 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3q27.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DVL3.

DRS3

Llyfryddiaeth

"Dishevelled segment polarity protein 3 (DVL3): a novel and easily applicable recurrence predictor in localised prostate adenocarcinoma. ". BJU Int. 2017. PMID 28107606.
"Dsh homolog DVL3 mediates resistance to IGFIR inhibition by regulating IGF-RAS signaling. ". Cancer Res. 2014. PMID 25168481.
"AMPK activators suppress cervical cancer cell growth through inhibition of DVL3 mediated Wnt/β-catenin signaling activity. ". PLoS One. 2013. PMID 23301094.
"Delicate analysis of post-translational modifications on Dishevelled 3. ". J Proteome Res. 2012. PMID 22612246.
"ALFY-Controlled DVL3 Autophagy Regulates Wnt Signaling, Determining Human Brain Size.". PLoS Genet. 2016. PMID 27008544.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] DVL3 - Cronfa NCBI

[1]

[2]