E2F5

E2F5
Dynodwyr
Cyfenwau	E2F5, E2F-5, E2F transcription factor 5
Dynodwyr allanol	OMIM: 600967 HomoloGene: 1472 GeneCards: E2F5
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • DNA binding; • transcription factor binding; • GO:0001948, GO:0016582 protein binding; • protein dimerization activity; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • sequence-specific DNA binding;
Cydrannau o'r gell	• cytoplasm; • nucleolus; • cnewyllyn cell; • transcription regulator complex; • nucleoplasm; • fibrillar center; • RNA polymerase II transcription regulator complex;
Prosesau biolegol	• animal organ morphogenesis; • regulation of cell cycle; • cell projection organization; • GO:0009373 regulation of transcription, DNA-templated; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • transcription, DNA-templated; • GO:1901227 negative regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologau
	1875
	n/a
	ENSG00000133740
	n/a
	Q15329
	n/a
	NM_001083588; NM_001083589; NM_001951
	n/a
	NP_001077057; NP_001077058; NP_001942
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn E2F5 yw E2F5 a elwir hefyd yn Transcription factor E2F5 ac E2F transcription factor 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 8, band 8q21.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn E2F5.

E2F-5

Llyfryddiaeth

"E2F5 as an independent prognostic factor in esophageal squamous cell carcinoma. ". Anticancer Res. 2013. PMID 24324077.
"Analysis of genetic aberrations on chromosomal region 8q21-24 identifies E2F5 as an oncogene with copy number gain in prostate cancer. ". Med Oncol. 2013. PMID 23377984.
"A potential oncogenic role of the commonly observed E2F5 overexpression in hepatocellular carcinoma. ". World J Gastroenterol. 2011. PMID 21274376.
"E2F5 status significantly improves malignancy diagnosis of epithelial ovarian cancer. ". BMC Cancer. 2010. PMID 20181230.
"Overexpression of E2F-5 correlates with a pathological basal phenotype and a worse clinical outcome.". Br J Cancer. 2009. PMID 19259095.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] E2F5 - Cronfa NCBI

[1]

[2]