EDC3

EDC3
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2VC8, 2WAX, 2WAY, 3D3J, 3D3K
Dynodwyr
Cyfenwau	EDC3, LSM16, YJDC, YJEFN2, MRT50, enhancer of mRNA decapping 3, hYjeF_N2-15q23
Dynodwyr allanol	OMIM: 609842 HomoloGene: 11827 GeneCards: EDC3
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001948, GO:0016582 protein binding; • phosphodiesterase decapping endonuclease activity; • identical protein binding; • RNA binding; • mRNA binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • bilen; • P-body; • cytoplasmic ribonucleoprotein granule;
Prosesau biolegol	• P-body assembly; • exonucleolytic catabolism of deadenylated mRNA; • RNA phosphodiester bond hydrolysis, endonucleolytic; • deadenylation-independent decapping of nuclear-transcribed mRNA;
	Sources:Amigo / QuickGO
Orthologau
	80153
	n/a
	ENSG00000179151
	n/a
	Q96F86
	n/a
	NM_001142443; NM_001142444; NM_025083; NM_001351378; NM_001351379
	n/a
	NP_001135915; NP_001135916; NP_079359; NP_001338307; NP_001338308
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EDC3 yw EDC3 a elwir hefyd yn Enhancer of mRNA-decapping protein 3 ac Enhancer of mRNA decapping 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 15, band 15q24.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EDC3.

YJDC
LSM16
MRT50
YJEFN2
hYjeF_N2-15q23

Llyfryddiaeth

"Crystal structure of human Edc3 and its functional implications. ". Mol Cell Biol. 2008. PMID 18678652.
"Mutations in DCPS and EDC3 in autosomal recessive intellectual disability indicate a crucial role for mRNA decapping in neurodevelopment. ". Hum Mol Genet. 2015. PMID 25701870.
"Structure of a Human 4E-T/DDX6/CNOT1 Complex Reveals the Different Interplay of DDX6-Binding Proteins with the CCR4-NOT Complex. ". Cell Rep. 2015. PMID 26489469.
"Edc3 function in yeast and mammals is modulated by interaction with NAD-related compounds. ". G3 (Bethesda). 2014. PMID 24504254.
"mRNA decapping factors and the exonuclease Xrn2 function in widespread premature termination of RNA polymerase II transcription.". Mol Cell. 2012. PMID 22483619.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] EDC3 - Cronfa NCBI

[1]

[2]