EFNA1

EFNA1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3HEI, 3MBW, 3CZU
Dynodwyr
Cyfenwau	EFNA1, B61, ECKLG, EFL1, EPLG1, LERK-1, LERK1, TNFAIP4, Ephrin A1, GMAN
Dynodwyr allanol	OMIM: 191164 HomoloGene: 3262 GeneCards: EFNA1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001948, GO:0016582 protein binding; • signaling receptor binding; • ephrin receptor binding;
Cydrannau o'r gell	• bilen; • Cellbilen; • integral component of plasma membrane; • anchored component of membrane; • extracellular exosome; • intracellular anatomical structure; • extracellular region; • anchored component of plasma membrane;
Prosesau biolegol	• regulation of cell adhesion mediated by integrin; • ephrin receptor signaling pathway; • aortic valve morphogenesis; • cell-cell signaling; • GO:1901227 negative regulation of transcription by RNA polymerase II; • regulation of angiogenesis; • mitral valve morphogenesis; • endocardial cushion to mesenchymal transition involved in heart valve formation; • regulation of blood vessel endothelial cell migration; • regulation of axonogenesis; • neuron differentiation; • notochord; • positive regulation of peptidyl-tyrosine phosphorylation; • substrate adhesion-dependent cell spreading; • cell migration; • negative regulation of epithelial to mesenchymal transition; • negative regulation of dendritic spine morphogenesis; • regulation of peptidyl-tyrosine phosphorylation; • negative regulation of thymocyte apoptotic process; • MAPK cascade; • angiogenesis; • axon guidance; • positive regulation of protein phosphorylation; • negative regulation of MAPK cascade; • positive regulation of MAPK cascade; • protein stabilization; • positive regulation of protein tyrosine kinase activity; • positive regulation of amyloid-beta formation; • positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process; • negative regulation of proteolysis involved in cellular protein catabolic process;
	Sources:Amigo / QuickGO
Orthologau
	1942
	n/a
	ENSG00000169242
	n/a
	P20827
	n/a
	NM_004428; NM_182685
	n/a
	NP_004419; NP_872626
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EFNA1 yw EFNA1 a elwir hefyd yn Ephrin A1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q22.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EFNA1.

B61
EFL1
ECKLG
EPLG1
LERK1
LERK-1
TNFAIP4

Llyfryddiaeth

"Regulation of endothelial migration and proliferation by ephrin-A1. ". Cell Signal. 2017. PMID 27742560.
"rs12904 polymorphism in the 3'UTR of EFNA1 is associated with colorectal cancer susceptibility in a Chinese population. ". Asian Pac J Cancer Prev. 2013. PMID 24175772.
"Ephrin-A1 mRNA is associated with poor prognosis of colorectal cancer. ". Int J Oncol. 2013. PMID 23258614.
"EphrinA1-EphA2 interaction-mediated apoptosis and FMS-like tyrosine kinase 3 receptor ligand-induced immunotherapy inhibit tumor growth in a breast cancer mouse model. ". J Gene Med. 2012. PMID 22228563.
"Ephs and ephrins in cancer: ephrin-A1 signalling.". Semin Cell Dev Biol. 2012. PMID 22040911.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] EFNA1 - Cronfa NCBI

[1]

[2]