EHD1

EHD1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2JQ6, 2KFF, 2KFG, 2KFH, 2KSP
Dynodwyr
Cyfenwau	EHD1, H-PAST, HPAST1, PAST, PAST1, EH domain containing 1
Dynodwyr allanol	OMIM: 605888 HomoloGene: 81678 GeneCards: EHD1
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nucleotide binding; • calcium ion binding; • GTP binding; • metal ion binding; • GO:0001948, GO:0016582 protein binding; • ATP binding; • cadherin binding; • identical protein binding;
Cydrannau o'r gell	• endosome; • cell projection; • early endosome membrane; • bilen; • lipid droplet; • Cellbilen; • cilium; • recycling endosome membrane; • platelet dense tubular network membrane; • ciliary membrane; • ciliary pocket membrane; • endosome membrane; • extracellular exosome;
Prosesau biolegol	• cellular response to nerve growth factor stimulus; • endocytosis; • low-density lipoprotein particle clearance; • positive regulation of cholesterol storage; • blood coagulation; • positive regulation of myoblast fusion; • cell projection organization; • protein localization to cilium; • positive regulation of endocytic recycling; • cholesterol homeostasis; • intracellular protein transport; • protein homooligomerization; • neuron projection development; • protein transport; • endocytic recycling; • cilium assembly; • GO:0015915 transport;
	Sources:Amigo / QuickGO
Orthologau
	10938
	n/a
	ENSG00000110047
	n/a
	Q9H4M9
	n/a
	NM_001282444; NM_001282445; NM_006795
	n/a
	NP_001269373; NP_001269374; NP_006786
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EHD1 yw EHD1 a elwir hefyd yn EH domain containing 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q13.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EHD1.

PAST
PAST1
H-PAST
HPAST1

Llyfryddiaeth

"Structural insight into the interaction of proteins containing NPF, DPF, and GPF motifs with the C-terminal EH-domain of EHD1. ". Protein Sci. 2009. PMID 19798736.
"Eps15 homology domain 1-associated tubules contain phosphatidylinositol-4-phosphate and phosphatidylinositol-(4,5)-bisphosphate and are required for efficient recycling. ". Mol Biol Cell. 2009. PMID 19369419.
"Mammalian Eps15 homology domain 1 promotes metastasis in non-small cell lung cancer by inducing epithelial-mesenchymal transition. ". Oncotarget. 2017. PMID 27531895.
"EHD1 confers resistance to cisplatin in non-small cell lung cancer by regulating intracellular cisplatin concentrations. ". BMC Cancer. 2016. PMID 27411790.
"Molecular dynamics simulation of the interactions between EHD1 EH domain and multiple peptides.". J Zhejiang Univ Sci B. 2015. PMID 26465136.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] EHD1 - Cronfa NCBI

[1]

[2]