EIF2S1

EIF2S1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1KL9, 1Q8K
Dynodwyr
Cyfenwau	EIF2S1, EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A, eukaryotic translation initiation factor 2 subunit alpha
Dynodwyr allanol	OMIM: 603907 HomoloGene: 3020 GeneCards: EIF2S1
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• translation initiation factor activity; • ribosome binding; • GO:0001948, GO:0016582 protein binding; • nucleic acid binding; • RNA binding;
Cydrannau o'r gell	• cytoplasm; • eukaryotic 48S preinitiation complex; • polysome; • cytosol; • ribosom; • bilen; • multi-eIF complex; • eukaryotic translation initiation factor 2B complex; • glial limiting end-foot; • translation initiation ternary complex; • cytoplasmic stress granule; • extracellular exosome; • cnewyllyn cell; • eukaryotic translation initiation factor 2 complex; • synapse;
Prosesau biolegol	• cellular response to heat; • positive regulation of type B pancreatic cell apoptotic process; • negative regulation of translational initiation in response to stress; • cellular response to UV; • cellular response to amino acid starvation; • GO:0010260 heneiddio; • response to endoplasmic reticulum stress; • PERK-mediated unfolded protein response; • response to manganese-induced endoplasmic reticulum stress; • transmembrane transport; • translational initiation; • protein autophosphorylation; • regulation of translation; • regulation of translational initiation in response to stress; • negative regulation of guanyl-nucleotide exchange factor activity; • positive regulation of neuron death; • protein biosynthesis; • stress granule assembly; • cellular response to oxidative stress;
	Sources:Amigo / QuickGO
Orthologau
	1965
	n/a
	ENSG00000134001
	n/a
	P05198
	n/a
	NM_004094
	n/a
	NP_004085
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EIF2S1 yw EIF2S1 a elwir hefyd yn Eukaryotic translation initiation factor 2 subunit 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q23.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EIF2S1.

EIF2
EIF-2
EIF2A
EIF-2A
EIF-2alpha

Llyfryddiaeth

"[Pro-survival signaling pathways activated by BCR-ABL oncogene in chronic myelogenous leukemia cells: the role of the perk-EIF2α signal path and acetylation of p53]. ". Postepy Biochem. 2014. PMID 25807820.
"Residues required for phosphorylation of translation initiation factor eIF2α under diverse stress conditions are divergent between yeast and human. ". Int J Biochem Cell Biol. 2015. PMID 25541374.
"Translational regulator eIF2α in tumor. ". Tumour Biol. 2014. PMID 24609900.
"6-Shogaol induces apoptosis in human leukemia cells through a process involving caspase-mediated cleavage of eIF2α. ". Mol Cancer. 2013. PMID 24215632.
"Eukaryotic initiation factor 2α phosphorylation mediates fetal hemoglobin induction through a post-transcriptional mechanism.". Blood. 2013. PMID 23690448.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] EIF2S1 - Cronfa NCBI

[1]

[2]