EIF4E2

EIF4E2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2JGB, 2JGC
Dynodwyr
Cyfenwau	EIF4E2, 4E-LP, 4EHP, EIF4EL3, IF4e, eukaryotic translation initiation factor 4E family member 2, h4EHP
Dynodwyr allanol	OMIM: 605895 HomoloGene: 128466 GeneCards: EIF4E2
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• RNA cap binding; • translation factor activity, RNA binding; • GO:0001948, GO:0016582 protein binding; • translation initiation factor activity; • ubiquitin protein ligase binding; • RNA binding; • RNA 7-methylguanosine cap binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • mRNA cap binding complex; • eukaryotic translation initiation factor 4F complex;
Prosesau biolegol	• translational initiation; • negative regulation of translation; • in utero embryonic development; • protein biosynthesis; • regulation of translation;
	Sources:Amigo / QuickGO
Orthologau
	9470
	n/a
	ENSG00000135930
	n/a
	O60573
	n/a
NM_001276336; NM_001276337; NM_001282958; NM_004846; NM_001330201;
	NM_001330202; NM_001330203
	n/a
NP_001263265; NP_001263266; NP_001269887; NP_001317130; NP_001317131;
	NP_001317132; NP_004837
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EIF4E2 yw EIF4E2 a elwir hefyd yn Eukaryotic translation initiation factor 4E family member 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2q37.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EIF4E2.

4EHP
IF4e
4E-LP
h4EHP
EIF4EL3

Llyfryddiaeth

"Cloning and characterization of 4EHP, a novel mammalian eIF4E-related cap-binding protein. ". J Biol Chem. 1998. PMID 9582349.
"Tristetraprolin Recruits Eukaryotic Initiation Factor 4E2 To Repress Translation of AU-Rich Element-Containing mRNAs. ". Mol Cell Biol. 2015. PMID 26370510.
"MicroRNAs recruit eIF4E2 to repress translation of target mRNAs. ". Protein Cell. 2017. PMID 28755203.
"Cancer cells exploit eIF4E2-directed synthesis of hypoxia response proteins to drive tumor progression. ". Cancer Res. 2014. PMID 24408918.
"Weak binding affinity of human 4EHP for mRNA cap analogs.". RNA. 2007. PMID 17369309.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] EIF4E2 - Cronfa NCBI

[1]

[2]