EIF4EBP1

EIF4EBP1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1EJ4, 1WKW, 2JGB, 2JGC, 2V8W, 2V8X, 2V8Y, 3HXG, 3HXI, 3M93, 3M94, 3U7X, 4UED, 5BXV
Dynodwyr
Cyfenwau	EIF4EBP1, 4E-BP1, 4EBP1, BP-1, PHAS-I, eukaryotic translation initiation factor 4E binding protein 1
Dynodwyr allanol	OMIM: 602223 HomoloGene: 3021 GeneCards: EIF4EBP1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• translation repressor activity; • GO:0001948, GO:0016582 protein binding; • eukaryotic initiation factor 4E binding; • translation initiation factor binding; • protein phosphatase 2A binding;
Cydrannau o'r gell	• cytosol; • cytoplasm; • cnewyllyn cell; • GO:0009327 protein-containing complex; • glutamatergic synapse; • postsynaptic cytosol;
Prosesau biolegol	• negative regulation of translation; • negative regulation of translational initiation; • positive regulation of mitotic cell cycle; • TOR signaling; • IRES-dependent translational initiation of linear mRNA; • regulation of translation; • GO:1901047 insulin receptor signaling pathway; • cellular response to dexamethasone stimulus; • G1/S transition of mitotic cell cycle; • response to ischemia; • lung development; • GO:0106160 negative regulation of protein-containing complex assembly; • response to ethanol; • cellular response to hypoxia; • response to amino acid starvation;
	Sources:Amigo / QuickGO
Orthologau
	1978
	n/a
	ENSG00000187840
	n/a
	Q13541
	n/a
	NM_004095
	n/a
	NP_004086
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EIF4EBP1 yw EIF4EBP1 a elwir hefyd yn Eukaryotic translation initiation factor 4E binding protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 8, band 8p11.23.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EIF4EBP1.

BP-1
4EBP1
4E-BP1
PHAS-I

Llyfryddiaeth

"Increased phosphorylation of 4Eâ€‘binding protein 1 predicts poor prognosis for patients with colorectal cancer. ". Mol Med Rep. 2017. PMID 28339030.
"Inhibitions of mTORC1 and 4EBP-1 are key events orchestrated by Rottlerin in SK-Mel-28 cell killing. ". Cancer Lett. 2016. PMID 27343979.
"Phosphorylated 4EBP1 is associated with tumor progression and poor prognosis in Xp11.2 translocation renal cell carcinoma. ". Sci Rep. 2016. PMID 27026382.
"4E-BP1, a multifactor regulated multifunctional protein. ". Cell Cycle. 2016. PMID 26901143.
"Cell type-specific abundance of 4EBP1 primes prostate cancer sensitivity or resistance to PI3K pathway inhibitors.". Sci Signal. 2015. PMID 26577921.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] EIF4EBP1 - Cronfa NCBI

[1]

[2]