ENO1

ENO1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2PSN, 3B97
Dynodwyr
Cyfenwau	ENO1, ENO1L1, MPB1, NNE, PPH, HEL-S-17, enolase 1
Dynodwyr allanol	OMIM: 172430 HomoloGene: 134343 GeneCards: ENO1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • metal ion binding; • GO:0001948, GO:0016582 protein binding; • lyase activity; • GTPase binding; • magnesium ion binding; • RNA binding; • cadherin binding; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • phosphopyruvate hydratase activity; • protein homodimerization activity; • RNA polymerase II transcription regulatory region sequence-specific DNA binding;
Cydrannau o'r gell	• cytoplasm; • M band; • bilen; • extracellular exosome; • cnewyllyn cell; • extracellular space; • phosphopyruvate hydratase complex; • cytosol; • Cellbilen; • cell surface; • cell cortex region;
Prosesau biolegol	• gluconeogenesis; • GO:0009373 regulation of transcription, DNA-templated; • glycolytic process; • response to virus; • transcription, DNA-templated; • negative regulation of cell growth; • GO:0045996 negative regulation of transcription, DNA-templated; • GO:1901227 negative regulation of transcription by RNA polymerase II; • positive regulation of plasminogen activation; • positive regulation of muscle contraction; • canonical glycolysis; • negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway; • positive regulation of ATP biosynthetic process;
	Sources:Amigo / QuickGO
Orthologau
	2023
	n/a
	ENSG00000074800
	n/a
	P06733
	n/a
	NM_001201483; NM_001428; NM_001353346
	n/a
	NP_001188412; NP_001419; NP_001340275
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ENO1 yw ENO1 a elwir hefyd yn Enolase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p36.23.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ENO1.

NNE
PPH
MPB1
ENO1L1
HEL-S-17

Llyfryddiaeth

"Peripheral ENO1-specific T cells mirror the intratumoral immune response and their presence is a potential prognostic factor for pancreatic adenocarcinoma. ". Int J Oncol. 2016. PMID 27210467.
"Soluble alpha-enolase activates monocytes by CD14-dependent TLR4 signalling pathway and exhibits a dual function. ". Sci Rep. 2016. PMID 27025255.
"Targeting the Warburg effect in cancer cells through ENO1 knockdown rescues oxidative phosphorylation and induces growth arrest. ". Oncotarget. 2016. PMID 26734996.
"CD4(+) T cell surface alpha enolase is lower in older adults. ". Mech Ageing Dev. 2015. PMID 26432922.
"Cellular stress induces cap-independent alpha-enolase/MBP-1 translation.". FEBS Lett. 2015. PMID 26144282.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] ENO1 - Cronfa NCBI

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[2]