EPAS1

EPAS1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1P97, 2A24, 3F1N, 3F1O, 3F1P, 3H7W, 3H82, 4GHI, 4GS9, 4PKY, 4XT2
Dynodwyr
Cyfenwau	EPAS1, ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73, endothelial PAS domain protein 1, Hypoxia-inducible factor-2alpha
Dynodwyr allanol	OMIM: 603349 HomoloGene: 1095 GeneCards: EPAS1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • protein dimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • transcription factor binding • GO:0001948, GO:0016582 protein binding • histone acetyltransferase binding • protein heterodimerization activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • cytosol • nuclear speck • transcription regulator complex • nucleoplasm • cnewyllyn cell Prosesau biolegol • surfactant homeostasis • cell differentiation • response to hypoxia • GO:0009373 regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter in response to oxidative stress • lung development • norepinephrine metabolic process • iron ion homeostasis • mitochondrion organization • embryonic placenta development • cell maturation • GO:0001306 response to oxidative stress • transcription, DNA-templated • regulation of heart rate • multicellular organism development • blood vessel remodeling • myoblast fate commitment • angiogenesis • regulation of transcription from RNA polymerase II promoter in response to hypoxia • erythrocyte differentiation • GO:0072468 signal transduction • golwg • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • cellular response to hypoxia • transcription by RNA polymerase II • post-translational protein modification • hemopoiesis • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • positive regulation of cold-induced thermogenesis • protein ubiquitination Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2034	n/a
Ensembl	ENSG00000116016	n/a
UniProt	Q99814	n/a
RefSeq (mRNA)	NM_001430	n/a
RefSeq (protein)	NP_001421	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EPAS1 yw EPAS1 a elwir hefyd yn Endothelial PAS domain protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2p21.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EPAS1.

• HLF
• MOP2
• ECYT4
• HIF2A
• PASD2
• bHLHe73

Llyfryddiaeth

• "Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia. ". PLoS One. 2017. PMID 28968430.
• "Evolutionary history of Tibetans inferred from whole-genome sequencing. ". PLoS Genet. 2017. PMID 28448578.
• "HIF-2α affects proliferation and apoptosis of MG-63 osteosarcoma cells through MAPK signaling. ". Mol Med Rep. 2017. PMID 28259908.
• "Down-Regulation of EPAS1 Transcription and Genetic Adaptation of Tibetans to High-Altitude Hypoxia. ". Mol Biol Evol. 2017. PMID 28096303.
• "Combined over-expression of the hypoxia-inducible factor 2α gene and its long non-coding RNA predicts unfavorable prognosis of patients with osteosarcoma.". Pathol Res Pract. 2016. PMID 27623205.

Cyfeiriadau

1. "Human PubMed Reference:".
2. EPAS1 - Cronfa NCBI