EPHA4

EPHA4
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2LW8, 2WO1, 2WO2, 2WO3, 3CKH, 3GXU, 4BK4, 4BK5, 4BKA, 4BKF, 4M4P, 4M4R, 4W4Z, 4W50, 5JR2
Dynodwyr
Cyfenwau	EPHA4, Epha4, 2900005C20Rik, AI385584, Cek8, Hek8, Sek, Sek1, Tyro1, rb, EPH receptor A4, HEK8, SEK, TYRO1, EK8
Dynodwyr allanol	OMIM: 602188 HomoloGene: 20933 GeneCards: EPHA4
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • protein kinase activity; • nucleotide binding; • GPI-linked ephrin receptor activity; • ephrin receptor binding; • DH domain binding; • transmembrane-ephrin receptor activity; • kinase activity; • GO:0001948, GO:0016582 protein binding; • identical protein binding; • transmembrane receptor protein tyrosine kinase activity; • PH domain binding; • protein tyrosine kinase activity; • ATP binding; • ephrin receptor activity; • amyloid-beta binding; • protein tyrosine kinase binding;
Cydrannau o'r gell	• cytoplasm; • axon terminus; • integral component of membrane; • cell body; • perikaryon; • postsynaptic membrane; • Golgi apparatus; • endosome; • cell projection; • early endosome membrane; • bilen; • GO:0097483, GO:0097481 postsynaptic density; • filopodium; • neuromuscular junction; • Cellbilen; • dendritic spine; • axonal growth cone; • integral component of plasma membrane; • synapse; • cell surface; • mitochondrial outer membrane; • cell junction; • axon; • dendrite; • early endosome; • Reticwlwm endoplasmig; • neuron projection; • dendritic shaft; • receptor complex; • Schaffer collateral - CA1 synapse; • glutamatergic synapse; • integral component of postsynaptic membrane; • integral component of presynaptic membrane;
Prosesau biolegol	• negative regulation of axon regeneration; • fasciculation of motor neuron axon; • phosphorylation; • transmembrane receptor protein tyrosine kinase signaling pathway; • positive regulation of JUN kinase activity; • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity; • nervous system development; • regulation of axonogenesis; • multicellular organism development; • protein phosphorylation; • regulation of astrocyte differentiation; • cell adhesion; • positive regulation of dendrite morphogenesis; • nephric duct morphogenesis; • protein autophosphorylation; • corticospinal tract morphogenesis; • peptidyl-tyrosine phosphorylation; • fasciculation of sensory neuron axon; • motor neuron axon guidance; • positive regulation of Rho guanyl-nucleotide exchange factor activity; • regulation of dendritic spine morphogenesis; • glial cell migration; • adult walking behavior; • axon guidance; • ephrin receptor signaling pathway; • negative regulation of neuron projection development; • protein stabilization; • positive regulation of protein tyrosine kinase activity; • neuron projection guidance; • synapse pruning; • neuron projection fasciculation; • negative regulation of long-term synaptic potentiation; • positive regulation of amyloid-beta formation; • positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process; • negative regulation of proteolysis involved in cellular protein catabolic process; • cellular response to amyloid-beta; • regulation of modification of synaptic structure;
	Sources:Amigo / QuickGO
Orthologau
	2043
	n/a
	ENSG00000116106
	n/a
	P54764
	n/a
	NM_001304536; NM_001304537; NM_004438; NM_001363748
	n/a
	NP_001291465; NP_001291466; NP_004429; NP_001350677
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EPHA4 yw EPHA4 a elwir hefyd yn EPH receptor A4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q36.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EPHA4.

SEK
HEK8
TYRO1

Llyfryddiaeth

"EPHA4 is overexpressed but not functionally active in Sézary syndrome. ". Oncotarget. 2015. PMID 26376612.
"Global evaluation of Eph receptors and ephrins in lung adenocarcinomas identifies EphA4 as an inhibitor of cell migration and invasion. ". Mol Cancer Ther. 2012. PMID 22807579.
"The Role of EphA4 Signaling in Radiation-Induced EMT-Like Phenotype in Colorectal Cancer Cells. ". J Cell Biochem. 2017. PMID 27632701.
"Lower and reduced expression of EphA4 is associated with advanced TNM stage, lymph node metastasis, and poor survival in breast carcinoma. ". Pathol Int. 2016. PMID 27478038.
"Regulation of EBV LMP1-triggered EphA4 downregulation in EBV-associated B lymphoma and its impact on patients' survival.". Blood. 2016. PMID 27338098.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] EPHA4 - Cronfa NCBI

[1]

[2]