EPS8

EPS8
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2E8M
Dynodwyr
Cyfenwau	EPS8, DFNB102, epidermal growth factor receptor pathway substrate 8
Dynodwyr allanol	OMIM: 600206 HomoloGene: 3272 GeneCards: EPS8
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• signaling adaptor activity; • GO:0001948, GO:0016582 protein binding; • actin binding;
Cydrannau o'r gell	• cytoplasm; • fesigl; • cell projection; • bilen; • GO:0097483, GO:0097481 postsynaptic density; • growth cone; • Cellbilen; • synapse; • NMDA selective glutamate receptor complex; • stereocilium; • ruffle membrane; • cell junction; • cell cortex; • brush border; • neuron projection; • extracellular exosome; • stereocilium bundle; • stereocilium tip; • glutamatergic synapse;
Prosesau biolegol	• actin cytoskeleton reorganization; • actin polymerization-dependent cell motility; • epidermal growth factor receptor signaling pathway; • regulation of actin filament length; • adult locomotory behavior; • barbed-end actin filament capping; • exit from mitosis; • actin filament bundle assembly; • dendritic cell migration; • actin crosslink formation; • regulation of cell shape; • behavioral response to ethanol; • cell population proliferation; • Rac protein signal transduction; • GO:0072468 signal transduction; • positive regulation of signal transduction; • cellular response to leukemia inhibitory factor; • Rho protein signal transduction; • regulation of Rho protein signal transduction; • regulation of postsynaptic membrane neurotransmitter receptor levels; • positive regulation of ruffle assembly;
	Sources:Amigo / QuickGO
Orthologau
	2059
	n/a
	ENSG00000151491
	n/a
	Q12929
	n/a
	NM_004447
	n/a
	NP_004438
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EPS8 yw EPS8 a elwir hefyd yn Epidermal growth factor receptor kinase substrate 8 ac Epidermal growth factor receptor pathway substrate 8 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12p12.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EPS8.

DFNB102

Llyfryddiaeth

"Epidermal growth factor receptor kinase substrate 8 promotes the metastasis of cervical cancer via the epithelial-mesenchymal transition. ". Mol Med Rep. 2016. PMID 27573546.
"Overexpression of EPS8 is associated with poor prognosis in patients with acute lymphoblastic leukemia. ". Leuk Res. 2015. PMID 25843487.
"Generation of cytotoxic T lymphocytes specific for native or modified peptides derived from the epidermal growth factor receptor pathway substrate 8 antigen. ". Cancer Immunol Immunother. 2015. PMID 25376540.
"Eps8 regulates cellular proliferation and migration of breast cancer. ". Int J Oncol. 2015. PMID 25333707.
"Real-time quantitative polymerase chain reaction assay for detecting the eps8 gene in acute myeloid leukemia.". Clin Lab. 2013. PMID 24409660.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] EPS8 - Cronfa NCBI

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[2]